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Structural Integration of Cerebellar Grafts in Ataxic Mouse Mutants

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Neural Transplantation in Cerebellar Ataxia

Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

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Abstract

There are many mutations in the laboratory mouse that interfere with the formation and maintenance of the cerebellar circuitry (refs. 1, 2 and chapter 4 in this book). The cerebellar lesion may consist in either defective positioning of specific neuronal populations or selective loss. Such mutations provide unique material for investigating developmental and degenerative events because: (i) the background on the cellular architecture and synaptic connections of the cerebellum is strong; (ii) the cerebellum is a relatively simple neuronal circuit for studying phenomena with general implications for the CNS and (iii) the molecular genetics and chromosomal structure have been characterized in the laboratory mouse better than in any other mammal. In addition to insight into cerebellar ontogeny, neurological mutants offer invaluable experimental models pertinent to the neuropathological lesions of the human cerebellar ataxias. A description of cerebellar transplantation studies in cerebellar mutants (Table 7.1) addressing various issues follows.

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  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Lazaros C. Triarhou M.D., Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Triarhou, L.C. (1997). Structural Integration of Cerebellar Grafts in Ataxic Mouse Mutants. In: Neural Transplantation in Cerebellar Ataxia. Neuroscience Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22213-3_7

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  • DOI: https://doi.org/10.1007/978-3-662-22213-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22215-7

  • Online ISBN: 978-3-662-22213-3

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