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Basic Studies on Cerebellar Tissue Transplantation

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Neural Transplantation in Cerebellar Ataxia

Part of the book series: Neuroscience Intelligence Unit ((NIU.LANDES))

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Abstract

As a rule, the genesis of neuronal populations, including Purkinje cells, is concluded during embryonic life, and the regenerative capacity of the adult CNS is confined to compensatory fiber sprouting and not mitotic divisions of nerve cells.1 Therefore, neurons that die as a result of regressive processes can only be replaced by implantation after harvesting from an external source. Intracerebral grafting of developing neuroblasts into the adult pathological brain has been successfully used to replace degenerated neurons in several experimental instances.2,3 In particular, primordial cerebellar tissue has been shown to survive and grow after orthotopic or heterotopic implantation into the adult rodent brain. An account of these studies is presented in this chapter. Cerebellar neuron grafting has also been applied to neurological mutant mice both to create appropriate confrontations between wild-type and mutant cells in elucidating gene effects on the involved lineage and to study the structural integration of transplanted wild-type Purkinje cells into the disrupted cerebellar loop; an account of cerebellar transplantation studies using ataxic mouse mutants is given in chapter 7.

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  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Lazaros C. Triarhou M.D., Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Triarhou, L.C. (1997). Basic Studies on Cerebellar Tissue Transplantation. In: Neural Transplantation in Cerebellar Ataxia. Neuroscience Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22213-3_6

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  • DOI: https://doi.org/10.1007/978-3-662-22213-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22215-7

  • Online ISBN: 978-3-662-22213-3

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