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Clinical Uses of Polyclonal and Monoclonal Antilymphoid Sera

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Monoclonal Antibodies in Transplantation

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

The early attempts at clinical transplantation were effectively limited to kidney transplants and relied on non-specific immunosuppression based on steroids and cytotoxic agents. The resulting poor graft survival (approximately 50% at one year for recipients of cadaver allografts) sparked research efforts to develop improved immunosuppressive protocols which specifically targeted the lymphocytes responsible for graft loss and spared the recipient unwanted side effects. Two major areas of emphasis emerged: biologic immunosuppressives consisting of antibody preparations directed against lymphocyte surface proteins and pharmacologic immunosuppressives consisting of drugs whose major effects were on lymphocyte metabolism.

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Authors
  1. Mary Ann Simpson
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  2. Anthony P. Monaco
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© 1995 Springer Science+Business Media Dordrecht

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Simpson, M.A., Monaco, A.P. (1995). Clinical Uses of Polyclonal and Monoclonal Antilymphoid Sera. In: Monoclonal Antibodies in Transplantation. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22195-2_1

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  • DOI: https://doi.org/10.1007/978-3-662-22195-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22197-6

  • Online ISBN: 978-3-662-22195-2

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