Signal Transduction in Mammalian Spermatozoa

  • G. S. Kopf
  • P. Kalab
  • P. Leclerc
  • X. P. Ning
  • D. Pan
  • P. Visconti
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 1)

Abstract

Intercellular communication between gametes is essential to the unique event in the life cycle of an organism called fertilization. Achievement of successful fertilization results from requisite and reciprocal cell-induced sperm and egg activation events mediated by unique cellular and environmental cues associated with either the gametes or the reproductive tract/environment. In the case of the sperm, the interaction of this highly motile cell with the female reproductive tract/environment, as well as with the egg both at a distance and in close proximity, represent a series of integrated processes designed to deliver sperm with optimal fertilizing potential to the site of fertilization. Recent studies have revealed that many aspects of gamete activation prior and subsequent to fertilization have similarities to intercellular and intracellular signaling systems utilized by somatic cells. Cell surface receptors or binding proteins on sperm for egg products have been identified in some species, while their identity in other species remains controversial. The occupancy of these receptors/binding proteins by egg products results in trans-membrane signaling and stimulation of intracellular effector systems, leading to subsequent sperm activation. Such activation events may include changes in motility, chemotaxis, and induction of acrosomal exocytosis, all of which may be essential prerequisites to successful fertilization in various species. This review will summarize what is known about these intercellular communicative events, with an emphasis on the mechanisms by which mammalian sperm process egg-associated signals via signal transduction pathways to effect changes in cellular function. The nature of these signaling systems is now being elucidated at the molecular level and has revealed some unique aspects of communication and transmembrane signaling between gametes. An understanding of signal transduction in mammalian sperm will ultimately yield information about the nature of the receptors to which these signal transduction pathways are coupled, as well as the intracellular effectors that ultimately regulate sperm function. Moreover, an understanding of these regulatory pathways will be essential for the future development of clinical approaches designed to enhance or preclude fertilization.

Keywords

Carbohydrate Dopamine Mold Polypeptide Luminal 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • G. S. Kopf
  • P. Kalab
  • P. Leclerc
  • X. P. Ning
  • D. Pan
  • P. Visconti

There are no affiliations available

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