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Molecular and Cellular Endocrinology of the Testis pp 37–65Cite as

Proliferation and Differentiation of Testicular Interstitial Cells: Aspects of Leydig Cell Development in the (Pre)Pubertal and Adult Testis

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Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 1))

Abstract

It has been known for several decades that the gonadotrophine luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are required for the normal growth and differentiation of Leydig cells and Sertoli cells, respectively (Greep et al. 1936; Christensen 1975). The actions of these gonadotrophins on the somatic cells of the testis result in the establishment of the appropriate microenvironment in the seminiferous tubule that is conducive to the process of spermatogenesis (Dorrington and Armstrong 1979). One of the essential factors for the progression of the process of spermatogenesis is testosterone. The gonadotrophin LH acts on Leydig cells to stimulate the synthesis and secretion of this androgen, which subsequently acts as a paracrine factor within the seminiferous tubules (Ahmad et al. 1973; Sharpe 1987).

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Authors
  1. K. J. Teerds
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  2. M. B. Veldhuizen-Tsoerkan
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  3. F. F. G. Rommerts
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  4. D. G. de Rooij
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  5. J. H. Dorrington
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G. Verhoeven U.-F. Habenicht

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Teerds, K.J., Veldhuizen-Tsoerkan, M.B., Rommerts, F.F.G., de Rooij, D.G., Dorrington, J.H. (1994). Proliferation and Differentiation of Testicular Interstitial Cells: Aspects of Leydig Cell Development in the (Pre)Pubertal and Adult Testis. In: Verhoeven, G., Habenicht, UF. (eds) Molecular and Cellular Endocrinology of the Testis. Ernst Schering Research Foundation Workshop, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22189-1_3

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