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The Nuclear Response to cAMP During Spermatogenesis: The Key Role of Transcription Factor CREM

  • P. Sassone-Corsi
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 1)

Abstract

The regulation of gene expression by specific signal transduction pathways is closely connected to the cell phenotype, and the response elicited by a given transduction pathway will vary according to the cell type. The finding that most of the known nuclear oncogenes encode proteins involved in the regulation of gene expression inspired the concept that the aberrant expression of some key genes could cause cellular transformation or altered proliferation (Lewin 1991). The study, and ultimately the understanding, of these processes will hopefully help us to unravel the profound changes that cause cancer and, by the same token, the physiology of normal growth.

Keywords

Follicle Stimulate Hormone Inducible cAMP Early Repressor Nuclear Response CREB Gene Adenylyl Cyclase Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • P. Sassone-Corsi

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