Hormonal Receptors in the Genital Tract
Hormonal receptors are rare and fragile molecules. Their study was difficult and often yielded contradictory results until immunological and molecular probes became available. Sex steroid receptor cDNAs were cloned in 1986–1987. Monoclonal antibodies had previously been prepared and for this reason the understanding of their structure and function is already very advanced to date. In contrast, gonadotropin receptors were not cloned until 1989–1990 and well-characterized antibodies still remain a problem in many cases and thus our knowledge of their mere basic structural and functional features is still preliminary in many cases.
KeywordsEstrogen Dopamine Acid Numbering Serine Oligomerization
Unable to display preview. Download preview PDF.
- Jonat C, Rahmsdorf HJ, Park KK, Cato ACB, Gebel S, Ponta H, Herrlich P (1990) Antitumor promotion and antiinflammation: down-modulation of API (Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1 189–1204Google Scholar
- Loosfelt H, Misrahi M, Atger M, Salesse R, Vu Hai MT, Jolivet A, GuiochonMantel A, Sar S, Jallal B, Gamier J, Milgrom E (1989) Cloning and sequencing of porcine LH/hCG receptor. Variants lacking transmembrane domain. Science 245: 525–528Google Scholar
- Misrahi M, Vu Hai MT, Ghinea N, Loosfelt H, Meduri G, Atger M, Jolivet A, Gross B, Savouret JF, Dessen P, Milgrom E (1993) Molecular and cellular biology of gonadotropin receptors. In: Adashi EY, Leung PC (eds) The ovary. Raven, New York, pp 57–92Google Scholar
- Schule R, Rangararajan P, Kliever S, Ransone LJ, Bolado J, Yang N, Verma 1M, Evans RM (1990) Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62: 1217–1226Google Scholar
- Tsai-Morris CH, Buczko E, Wang W, Xie XZ, Dufau ML (1991) Structural organization of the rat luteinizing hormone ( LH) receptor gene. J Biol Chem 266: 11355–11359Google Scholar