Skip to main content

Klinische Studien zum Magenkarzinom: Folgerungen der „Gastrointestinal Tumor Study Group“ (GITSG) und Erfahrungen des „Mount Sinai Medical Center“

  • Conference paper
  • 22 Accesses

Zusammenfassung

Die Erfahrungen der GITSG sind sehr lehrreich. Ärzte können früher gemachte Fehler vermeiden und multidisziplinäre Behandlungsstrategien von nachgewiesenem therapeutischen Nutzen weiterentwickeln. Die Studien wurden an ausreichend großen Patientenzahlen durchgeführt, um herauszufinden, inwieweit bestimmte Therapieverfahren möglicherweise für kleine Patientenuntergruppen vorteilhaft sind. Die Summe mehrerer unterschiedlicher Therapieverfahren, von denen jedes einzelne nur begrenzt anwendbar erscheinen mag, gibt jedem Arzt in der Praxis etwas für den Großteil seiner Patienten in die Hand. Als Folgerung daraus ist es notwendig, die für jeden einzelnen Patienten spezifischen Merkmale zu ermitteln. Diese Übersicht wird sich auf die Beobachtungen konzentrieren, die für den erstbehandelnden Gastroenterologen oder Chirurgen relevant sind.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Gastrointestinal Tumor Study Group (1979) Phase II-III chemotherapy studies in advanced gastric cancer. Cancer Treat Rep 63:1871

    Google Scholar 

  2. Gastrointenstinal Tumor Study Group (1982) A comparative clincal assessment of combination chemotherapy in the management of advanced gastric carcinoma. Cancer 49: 1362

    Article  Google Scholar 

  3. Gastrointenstinal Tumor Study Group (1984) Randomized study of combination chemotherapy in unresectable gastric cancer. Cancer 53: 13

    Article  Google Scholar 

  4. Bruckner HW, Lokich JJ, Stablein DM (1982) Studies of Baker’s antifol, methotrexate, and Razoxane in advanced gastric cancer. A Gastrointestinal Tumor Study Group Report. Cancer Treat Rep 66: 1713

    PubMed  CAS  Google Scholar 

  5. Bruckner HW, Stablein DM, für the Gastrointestinal Tumor Study Group (1986) A randomized study of 5-fluorouracil and doxorubicin with semustine, cisplatin, or triazinate for treatment of advanced gastric cancer, abstract. Proc ASCO 5: 90

    Google Scholar 

  6. O’Connell MJ (1985) Current status of chemotherapy for advanced pancreatic and gastric cancer. J Clin Oncol 3: 1032

    PubMed  Google Scholar 

  7. Douglass HO Jr, Lavin PT, Goudsmit A, et al (1984) An Eastern Cooperative Oncology Group evaluation of combinations of methyl-CCNU, mitomycin-C, Adriamycin, and 5-fluorouracil in advanced measurable gastric cancer (EST 2277). J Clin Oncol 2:1372

    PubMed  Google Scholar 

  8. Klein HI, Dias Wichramanayake P, Farrokh GR (1986) 5-Fluorouracil, Adriamycin, and methotrexate — a combination protocol for treatment of metastasized stomach cancer. Proc ASCO 5: 84

    Google Scholar 

  9. Wils J, Bleigerg H, Dalesio O, et al (1986) An EORTC gastrointestinal group evaluation of the combination of sequential methotrexate and 5-fluorouracil, combined with Adriamycin in advanced measurable gastric cancer. J Clin Oncol 4: 1799

    PubMed  CAS  Google Scholar 

  10. Preusser P, Wilke H, Achterrath W, et al (1987) Advanced gastric carcinoma: A phase II study with etoposide, Adriamycin and split course cisplatin. Proc ASCO 6: 75

    Google Scholar 

  11. Bruckner HW, Stablein DM, für the Gastrointestinal Tumor Study Group (1984) Single arm trials of triazinate, cisplatin and methotrexate combinations in advanced gastric cancer, abstract. Proc ASCO 3: 144

    Google Scholar 

  12. O’Connell MJ, Schutt AJ, Moertel CG, Hahn RG (1987) Phase II clinical trial of triazinate in combination with mitomycin C for patients with advanced gastric cancer. J Clin Oncol 5: 83

    PubMed  Google Scholar 

  13. Bruckner HW, Cohen J (1983) MTX/5-FU trials in gastrointestinal and other cancers. Sem Oncol 10: 32

    CAS  Google Scholar 

  14. Houghton JA, Houghton PJ (1984) Basis for the interaction of 5-fluorouracil and leucovorin in colon adenocarcinoma, in Bruckner HW, Rustum YM (eds): Advances in Cancer Chemotherapy: The Current Status of 5-Flourouracil-Leucovorin Calcium Combination. Park Row, New York, p 23

    Google Scholar 

  15. Machover D, Schwarzenberg L, Goldschmidt E et al (1982) Treatment of advanced colorectal and gastric adenocarcinomas with 5-FU combined with high-dose folinic acid: a pilot study. Cancer Treat Rep 66: 1803

    PubMed  CAS  Google Scholar 

  16. Arbuck SG, Douglass HO Jr, Trave F et al (1987) A phase II trial of 5-flourouracil and high-dose intravenous leucovorin in gastric carcinoma. J Clin Oncol 5: 1150

    PubMed  CAS  Google Scholar 

  17. Trave F, Rustum YM, Goranson J (1985) Synergistic antitumor activity of cisplatin and 5-fluorouracil in mice bearing leukemia L 1210 cells, abstract. Proc ASCO 26: 322

    Google Scholar 

  18. Burchenal JH, Lokys L, Turkevich J, Gale G (1980) Rationale of combination chemotherapy, in Prestayko AW, Crooke ST, Carter SK (eds): Cisplatin: Current Status and New Developments. Academic, New York, p 113

    Google Scholar 

  19. Bruckner HW, Stablein DM, für the Gastrointestinal Tumor Study Group (1983) Sites of treatment failure: Gastrointenstinal Tumor Study Group Analyses of gastric, pancreatic and colorectal trials. Cancer Treat Sym 2: 199

    Google Scholar 

  20. Lavin PT, Bruckner HW, Plaxe SC, for the Gastrointestinal Tumor Study Group (1983) Studies in prognostic factors relating to chemotherapy for advanced gastric cancer. Cancer 50: 2016

    Article  Google Scholar 

  21. Bruckner HW, Lavin P, Plaxe S, et al (1983) Routine clinical chemistries as improved determinates of prognosis for patients with metastatic cancer of the stomach. Oncology 40: 31

    Article  PubMed  CAS  Google Scholar 

  22. Brucker HW, Lavin PT, Plaxe SC et al (1982) Absolute granulocyte, lymphocyte and monocyte counts. Useful determinants of prognosis for patients with metastatic cancer of the stomach. JAMA 274: 1004

    Google Scholar 

  23. Gastrointestinal Tumor Study Group (1982) A comparison of combination chemotherapy and combined modality for locally advanced gastric carcinoma. Cancer 49: 1771

    Article  Google Scholar 

  24. Stablein DM, Carter WH et al (1981) Analysis of survival data with nonproportional hazard functions. Control Clin Trials 2: 149

    Article  PubMed  CAS  Google Scholar 

  25. Kemeny N, Daly J, Reichman B et al (1987) Intrahepatic or systemic infusion of flourode-oxyuridine in patient with liver metastases from colorectal carcinoma. Ann Intern Med 107: 459

    Article  PubMed  CAS  Google Scholar 

  26. Krook J, Moertel C, Wieand H et al (1986) Radiation vs sequential chemotherapy-radiation-chemotherapy. A study of the North Central Cancer Treatment Group, Duke University, and the Mayo Clinic. Proc ASCO 5: 82

    Google Scholar 

  27. Moertel CG, Childs DS, Reitemeirer RJ, et al (1969) Conbined 5-fluorouracil and supervolt-age radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2: 865

    Article  PubMed  CAS  Google Scholar 

  28. Gastrointenstinal Tumor Study Group (1979) A multi-institutional comparative trial of radiation therapy alone and in combination with 5-fluorouracil for locally unresectable pancreatic carcinoma. Ann Surg 189: 126

    Google Scholar 

  29. Gastrointestinal Tumor Study Group (1985) Prolongation of the disease-agree interval in surgically treted rectal carcinoma. N Engl J Med 312: 1465

    Article  Google Scholar 

  30. Wolmark N, Fisher B, Rockette H, et al (1987) Adjuvant therapy in carcinoma of the colon: five years results of NSABP protocol C-01. Proc ASCO 6: 92

    Google Scholar 

  31. Fisher B, Wolmark N, Rockette H et al (1987) Adjuvant chemotherapy or post-operative radiation for rectal cancer: 5-year results of NSABP R-01. Proc ASCO 6: 92

    Google Scholar 

  32. Bruckner HW (1988) Letter to the Editor. Am J Gastroenterol, to be published

    Google Scholar 

  33. Nakazato H, Imanaga H (1979) Results of surgery for gastric cancer and effect of adjuvant chemotherapy, in Herfarth CH, Schlag P (eds): Gastric Cancer. Springer, Berlin Heidelberg New York, p 344

    Chapter  Google Scholar 

  34. Douglass HO, Stablein D, Brukcern HW et al (1982) Controlled trial of adjuvant chemotherapy following curative resection for gastric cancer. Cancer 49: 1116

    Article  Google Scholar 

  35. Kabakow B, Storch JA, Bruckner HW (1977) New multidisciplinary treatment for gastric carcinoma. Digestion 16: 248

    Google Scholar 

  36. Douglass HO Jr: Western Surgical adjuvant trials in gastric cancers: lessons from currentrials to be applied to the future, in: Contemporary Issues in Clinical Oncology. Churchill-Livingston, New York, p 145

    Google Scholar 

  37. Douglass HO Jr (1985) Adjuvant chemotherapy-stomach cancer-adjuvant treatment of gastric cancer, in: Cancer Chemotherapy: Challenges for the Future. First Nagoya Intern Symp on Cancer Treatment. Excerpta Medica International Congress Series 729

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Bruckner, H.W. (1989). Klinische Studien zum Magenkarzinom: Folgerungen der „Gastrointestinal Tumor Study Group“ (GITSG) und Erfahrungen des „Mount Sinai Medical Center“. In: Hotz, J., et al. Magenkarzinom. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22121-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-22121-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19001-1

  • Online ISBN: 978-3-662-22121-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics