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Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations

  • Chapter
Long Circulating Liposomes: Old Drugs, New Therapeutics

Part of the book series: Biotechnology Intelligence Unit ((BIOIU))

Abstract

Vincristine is an alkaloid derived from Vinca rosea that is effective against a wide variety of human carcinomas.1,2 When used in conjunction with corticosteroids, vincristine is the treatment of choice to induce remissions in childhood leukemia. Vincristine is also part of a complex protocol used in the treatment of adult patients with Hodgkin’s disease or non-Hodgkin’s lymphomas. In addition, vincristine has some effectiveness against Wilms’ tumor, neuroblastoma, brain tumors, rhabdomyosarcoma, and carcinomas of the breast and the bladder, as well as the male and female reproductive systems.

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Authors
  1. Nancy L. Boman
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  2. Pieter R. Cullis
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  3. Lawrence D. Mayer
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  4. Marcel B. Bally
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  5. Murray S. Webb
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Editor information

Editors and Affiliations

  1. Genetic Therapy, Inc., Gaithersburg, Maryland, USA

    Martin C. Woodle Ph.D.

  2. Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands

    Gerrit Storm Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Boman, N.L., Cullis, P.R., Mayer, L.D., Bally, M.B., Webb, M.S. (1998). Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations. In: Woodle, M.C., Storm, G. (eds) Long Circulating Liposomes: Old Drugs, New Therapeutics. Biotechnology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22115-0_3

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  • DOI: https://doi.org/10.1007/978-3-662-22115-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22117-4

  • Online ISBN: 978-3-662-22115-0

  • eBook Packages: Springer Book Archive

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