Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations
Vincristine is an alkaloid derived from Vinca rosea that is effective against a wide variety of human carcinomas.1,2 When used in conjunction with corticosteroids, vincristine is the treatment of choice to induce remissions in childhood leukemia. Vincristine is also part of a complex protocol used in the treatment of adult patients with Hodgkin’s disease or non-Hodgkin’s lymphomas. In addition, vincristine has some effectiveness against Wilms’ tumor, neuroblastoma, brain tumors, rhabdomyosarcoma, and carcinomas of the breast and the bladder, as well as the male and female reproductive systems.
KeywordsDrug Release Antitumor Efficacy Drug Release Rate Large Unilamellar Vesicle Drug Retention
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