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Antibody-Mediated Targeting of PEG-Coated Liposomes

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Long Circulating Liposomes: Old Drugs, New Therapeutics

Part of the book series: Biotechnology Intelligence Unit ((BIOIU))

Abstract

For two decades the liposome has been portrayed as a classic example of a “magic bullet” concept. A targeting ligand, preferably a target-specific antibody, would be immobilized at the liposome surface, so it would specifically bind only to the target tissue.1 After iv administration, this immunoliposome would carry a drug for selective delivery to the disease site. Neither drug delivery to normal tissues nor harmful side effects would occur. However, numerous technical problems had to be solved before this concept became feasible.

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Authors
  1. Alexander L. Klibanov
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Editors and Affiliations

  1. Genetic Therapy, Inc., Gaithersburg, Maryland, USA

    Martin C. Woodle Ph.D.

  2. Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands

    Gerrit Storm Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Klibanov, A.L. (1998). Antibody-Mediated Targeting of PEG-Coated Liposomes. In: Woodle, M.C., Storm, G. (eds) Long Circulating Liposomes: Old Drugs, New Therapeutics. Biotechnology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22115-0_19

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  • DOI: https://doi.org/10.1007/978-3-662-22115-0_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22117-4

  • Online ISBN: 978-3-662-22115-0

  • eBook Packages: Springer Book Archive

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