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Sterically Stabilized Liposomes to Image Infection and Inflammation

  • Chapter
Long Circulating Liposomes: Old Drugs, New Therapeutics

Part of the book series: Biotechnology Intelligence Unit ((BIOIU))

Abstract

Determination of the localization of acute, subacute and chronic infectious foci may have important implications for the management of patients. Imaging techniques like ultrasound, CT-scanning or MRI are in most cases unable to discriminate active processes from scar tissue due to a cured infection or after surgery. In contrast, scintigraphic images are not determined morphologically, they are based on physiochemical processes in tissues. In clinical practice not only the presence of an active inflammatory process, but also the localization and the number of foci needs to be determined; scintigraphic imaging is an excellent noninvasive method of whole-body scanning. In clinical practice several radiopharmaceuticals are used to image foci of infection and inflammation. In this chapter the development and the potential of a liposome-based radiopharmaceutical for infection and inflammation imaging is described and compared with conventional radiopharmaceuticals.

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References

  1. Lavender JP, Lowe J, Barker JR, Burn JI, Chaudri MA. Gallium-67 citrate scanning in neoplastic and inflammatory lesions. Brit J Radiol 1971; 44:361-366.

    Google Scholar 

  2. Ito Y, Okuyama S, Awano T, Takahashi K, Sato T, Kanno I. Diagnostic evaluation of Ga-67 scanning of lung cancer and other diseases. Radiology 1971; 101:355-362.

    Google Scholar 

  3. Staab EV, McCartney WH. Role of gallium-67 in inflammatory disease. Semin Nucl Med 1978; 8:219-234.

    Google Scholar 

  4. Siemsen JK, Gebe SF, Waxman AD. The use of gallium-67 in pulmonary disorders. Semin Nucl Med1978; 8:235-249•

    Google Scholar 

  5. McAfee JG, Thakur ML. Survey of radioactive agents for the in vitro labeling of phagocytic leucocytes. I Soluble agents. II Particles. J Nucl Med 1976; 17: 480–492.

    PubMed  CAS  Google Scholar 

  6. Peters AM, Danpure HJ, Osman S, Hawker RJ, Henderson BL, Hodgson HJ, Kelly JD, Neirinckx RD, Lanvender JP. Clinical experience with Tc-99m-HMPAO for labelling leucocytes and imaging infection. Lancet1986; 2: 946–949.

    Google Scholar 

  7. Froelich JW, Swanson D. Imaging of inflammatory processes with labeled cells. Semin Nucl Med 1984; 14: 128–14o.

    Article  PubMed  CAS  Google Scholar 

  8. Baba AA, McKillop JH, Cuthbert GF, Neilson W, Gray HW, Anderson JR. Indium-ni leucocyte scintigraphy in abdominal sepsis: do the results affect management? Eur J Nucl Med 1990; 16:307-309.

    Google Scholar 

  9. Coleman RE. Radiolabeled leukocytes. In: Freeman LM, Weissmann HS, eds. Nuclear Medicine Annual 1982. New York: Raven Press 1982: 119–141.

    Google Scholar 

  10. Lange JMA, Boucher CAB, Hollak CEM, Wiltink EH, Reiss P, van Royen EA, Roos M, Danner SA, Goudsmit J. Failure of zidovudine prophylaxis after accidental exposure to HIV-1. N Eng J Med 1990; 323: 915–916.

    Google Scholar 

  11. Rubin RH, Fischman AJ, Callahan RJ, Khaw BA, Keech F, Ahmad M, Wilkinson R, Strauss HW. “’In-labeled nonspecific immunoglobulin scanning in the detection of focal infection. N Eng J Med 1989; 321:935-940.

    Google Scholar 

  12. Oyen WJG, Claessens RAMJ, van der Meer JWM, Rubin RH, Strauss HW, Corstens FHM. Indium-111-labeled human nonspecific immunoglobulin G: A new radio-pharmaceutical for imaging infectious and inflammatory foci. Clin Infect Dis 1992; 14: 1110–1119.

    Google Scholar 

  13. Oyen WJG, van Horn JR, Claessens RAMJ, Slooff TJJH, van der Meer JWM, Corstens FHM. Diagnosis of bone, joint and joint prothesis infections with indium-in labeled nonspecific human immunoglobulin G scintigraphy. Radiology 1992; 182: 195–199.

    Google Scholar 

  14. Oyen WJG, Claessens RAMJ, van der Meer JWM, Corstens FHM. Detection of subacute infectious foci with indium-111 labeled autologous leukocytes and indium-ill labeled human nonspecific immunoglobulin G: a prospective comparative study. J Nucl Med 1991; 32: 1854–1860.

    Google Scholar 

  15. Oyen WJG, Claessens RAMJ, Raemaekers JMM, de Pauw BE, van der Meer JWM, Corstens FHM. Diagnosing infection in febrile granulocytopenic patients with indium-ill labeled human IgG. J Clin Oncol 1992; 10: 61–68.

    Google Scholar 

  16. Oyen WIG, Netten PM, Lemmens JAM, Claessens RAMJ, Lutterman JA, van der Vliet JA, Goris JA, van der Meer JWM, Corstens FHM. Evaluation of infectious diabetic foot complications with Indium-1n-labeled human nonspecific immunoglobulin G. J Nucl Med 1992; 33: 1330–1336.

    Google Scholar 

  17. De Klein EMHA, Oyen WJG, Claessens RAMJ, Corstens FHM, van der Meer JWM. Arch Intern Med 1995; 155:1989-1994.

    Google Scholar 

  18. Blok D, van Ogtrop M, Arndt JW, Camps JAJ, Feitsma RIJ, Goedemans W, Pauwels EKJ. Detection of inflammatory lesions with radiolabelled immunoglobulins. Eur J Nucl Med 1990; 16: 303–305.

    Article  PubMed  CAS  Google Scholar 

  19. Buscombe JR, Lui D, Ensing G, de Jong R, Ell PJ. [99mTc]human immunoglobulin (HIG)-first results of a new agent for the localization of infection and inflammation. Eur J Nucl Med 1990; 16:649-655.

    Google Scholar 

  20. Claessens RAW, Boerman OC, Koenders EB, Oyen WJG, van der Meer JWM, Corstens FHM. Technetium-99m labelled hydrazinonicotinamido human non-specific polyclonal immunoglobulin G for detection of infectious foci: a comparison with two other technetium-labelled immunoglobulin preparations. Eur J Nucl Med 1996; 23: 414–421.

    Article  PubMed  CAS  Google Scholar 

  21. Nässander UK, Storm G, Peeters PAM, Crommelin DIA. Liposomes. In: Biodegradable Polymers as Drug Delivery Systems (eds. M. Chasin, R. Langer ), New York: Marcel Dekker, 1990; 261–338.

    Google Scholar 

  22. Crommelin DNA, Schreier H. Liposomes. In: Colloidal Drug Delivery Systems (J. Kreuter, ed.). New York: Marcel Dekker Inc, 1994; 73-89.

    Google Scholar 

  23. Jain RK. Determinants of tumor blood flow: A review. Cancer Res 1988; 48: 2641–2658.

    PubMed  CAS  Google Scholar 

  24. Morrel EM, Tompkins RG, Fischman AJ, Wilkinson RA, Burke JF, Rubin RH, Strauss HW, Yarmush ML. Autoradiographic method for quantitation of radiolabeled proteins in tissues using Indium-u1. J Nucl Med 1989; 30:1538–1545.

    Google Scholar 

  25. Juweid M, Strauss HW, Yaoita H, Rubin RH, Fischman AJ. Accumulation of immunoglobulin G at focal sites of inflammation. Eur J Nucl Med 1992; 19: 159–165.

    Article  PubMed  CAS  Google Scholar 

  26. Morgan JR, Williams KE, Davies RL, Leach K, Thomson M, Williams LAP. Localisation of experimental staphylococcal abscesses by [99mTc]technetium-labelled liposomes. J Med Microbiol 1981; 14: 213–217.

    Article  PubMed  CAS  Google Scholar 

  27. Morgan JR, Williams LA, Howard CB. Technetium-labelled liposome imaging for deep-seated infection. Br J Radiol 1985; 58: 35–39.

    Google Scholar 

  28. Williams BD, O’Sullivan MM, Saggu GS, Williams KE, Williams LA, Morgan JR. Synovial accumulation of technetium labelled liposomes in rheumatoid arthritis. Ann Rheum Dis 1987; 46: 314–318.

    Google Scholar 

  29. O’Sullivan MM, Powell N, French AP, Williams KE, Morgan JR, Williams BD. Inflammatory joint disease: a comparison of liposome scanning, bone scanning, and radiography. Ann Rheum Dis 1988; 47:485-491.

    Google Scholar 

  30. Love WG, Amos N, Kellaway IW, Williams BD. Specific accumulation of cholesterol-rich liposomes in the inflammatory tissue of rats with adjuvant arthritis. Ann Rheum Dis 1990; 49: 611–614.

    Google Scholar 

  31. Barratt GM, Tuzel NS, Tyman BE. The labeling of liposomal membranes with radioactive technetium. In: Gregoriadis G, ed. Liposome technology, volume II. Boca Raton, FL: CRC Press 1984; 94-105.

    Google Scholar 

  32. Senior JH. Fate and behavior of liposomes in vivo: a review of controlling factors. Crit Rev Ther Drug Carrier Syst 1987; 3123-193.

    Google Scholar 

  33. Liu D, Mori A, Huang L. Large liposomes containing ganglioside GM, accumulate effectively in spleen. Biochim Biophys Acta 1991; 1066: 159–165.

    Article  PubMed  CAS  Google Scholar 

  34. Allen TM, Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothial system. FEBS Lett 1987; 223: 42–46.

    Article  PubMed  CAS  Google Scholar 

  35. Bakker-Woudenberg IAJM, Lokerse AF, ten Kate MT, Storm G. Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue. Biochim Biophys Acta 1992; 1138: 318–326.

    Article  PubMed  CAS  Google Scholar 

  36. Bakker Woudenberg IA, Lokerse AF, ten Kate MT, Mouton JW, Woodle MC, Storm G. Liposomes with prolonged blood circulation and selective localization in Klebsiella pneumoniae-infected lung tissue. J Infect Dis 1993; 168: 164–171.

    Google Scholar 

  37. Gabizon A, Papahadjopoulos D. Liposome formulation with prolonged circulation time in blood and enhanced uptake by tumors. Proc Natl Acad Sci USA 1988; 85: 6949–6953.

    Article  PubMed  CAS  Google Scholar 

  38. Allen TM, Hansen C, Martin F, Redemann C, Yan-Young A. Liposomes containing synthetic lipid derivatives of polyethylene glycol show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1991; 1066: 29–36.

    Article  PubMed  CAS  Google Scholar 

  39. Blume G, Cevc G. Liposomes for the sustained drug release in vivo. Biochim Biophys Acta 1990; 1029:91-97.

    Google Scholar 

  40. Klibanov AL, Maruyama K, Torchilin VP et al. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett 1990; 268:235-237.

    Google Scholar 

  41. Storm G, Belliot SO, Daemen T, Lasic DD. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system. Adv Drug Delivery Rev 1995; 17: 31–48.

    Google Scholar 

  42. Goins B, Klipper R, Rudolph AS, Cliff RO, Blumhardt R, Phillips WT. Biodistribution and imaging studies of technetium-99m-labeled liposomes in rats with focal infection. J Nucl Med 1993; 34: 2160–2168.

    Google Scholar 

  43. Boerman OC, Storm G, Oyen WJG, van Bloois L, van der Meer JWM, Claessens RAMJ, Crommelin DJA, Corstens FHM. Sterically stabilized liposomes labeled with indium-ni to image focal infection in rats. J Nucl Med 1995; 36:1639-i644.

    Google Scholar 

  44. Phillips WT, Rudolf AS, Goins B, Timmons JH, Klipper R, Blumhardt R. A simple method for producing a technetium-99m-labeled liposome which is stable in vivo. Nucl Med Biol 1992; 19:539-547.

    Google Scholar 

  45. Oyen WJG, Boerman OC, Storm G, van Bloois L, Koenders EB, Claessens RAMJ, Perenboom RM, Crommelin DJA, van der Meer JWM, Corstens FHM. Detecting infection and inflammation with 99mTc labeled Stealth® liposomes. J Nucl Med 1996; 37: 1392–1397.

    PubMed  CAS  Google Scholar 

  46. Boerman OC, Oyen WJG, van Bloois L, van der Meer JWM, Koenders EB, Claessens RAMJ, Crommelin DJA, Corstens FHM, Storm G. Optimization of technetium-qqmlabeled PEG-liposomes to image focal infection: effects of particle size and circulation time. J Nucl Med 1997; 38: 489–493.

    Google Scholar 

  47. Oyen WJG, Boerman OC, Storm G, van Bloois L, Koenders EB, Crommelin DJA, van der Meer JWM, Corstens FHM. Labeled Stealth° liposomes in experimental infection: an alternative to leukocyte scintigraphy? Nuclear Med Commun 17; 742–748, 1996.

    Google Scholar 

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Authors
  1. Otto C. Boerman
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  2. Wim J. G. Oyen
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  3. Frans H. M. Corstens
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  4. Gerrit Storm
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Editor information

Editors and Affiliations

  1. Genetic Therapy, Inc., Gaithersburg, Maryland, USA

    Martin C. Woodle Ph.D.

  2. Department of Pharmaceutics, University of Utrecht, Utrecht, The Netherlands

    Gerrit Storm Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Boerman, O.C., Oyen, W.J.G., Corstens, F.H.M., Storm, G. (1998). Sterically Stabilized Liposomes to Image Infection and Inflammation. In: Woodle, M.C., Storm, G. (eds) Long Circulating Liposomes: Old Drugs, New Therapeutics. Biotechnology Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22115-0_16

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  • DOI: https://doi.org/10.1007/978-3-662-22115-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22117-4

  • Online ISBN: 978-3-662-22115-0

  • eBook Packages: Springer Book Archive

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