AmBisome®: Long Circulating Liposomal Formulation of Amphotericin B

  • Jill P. Adler-Moore
  • Richard T. Proffitt
Part of the Biotechnology Intelligence Unit book series (BIOIU)


AmBisome® is a newly commercialized formulation of amphotericin B incorporated into small unilamellar liposomes composed of cohesive bilayer forming lipids (see chapter 1). An important feature of this formulation is that the amphotericin B is stably incorporated into the liposome bilayer.1 In recent years, this and other lipid formulations have been devised to improve the utility of Fungizone, a micellar formulation of amphotericin B which rapidly disassociates upon iv administration. While the standard formulation is proven clinically, it is limited by severe renal toxicity, and many life-threatening fungal infections cannot successfully be treated.2,3 For the purposes of this chapter, Fungizone is considered “free” amphotericin B (ampB) administration.


Visceral Leishmaniasis Kidney Tissue Aspergillus Fumigatus Antimicrobial Chemotherapy Liposomal Amphotericin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Jill P. Adler-Moore
  • Richard T. Proffitt

There are no affiliations available

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