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Sertoli Cells in Islet Transplantation: Testicular Immune Privilege

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Local Immunosuppression of Organ Transplants

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

The transplantation of pancreatic islets is the most physiologic and desirable form of therapy for establishment of normoglycemia and prevention of complications in the diabetic patient. In rodents, longterm survival of islet allo- and even xenografts can be achieved with a high degree of success.1–6 The promising results reported in rodents were met with optimism and enthusiasm, and advances toward clinical application of islet transplantation were predicted at regular intervals. Unfortunately, successful islet transplantation in larger animals, and in particular, in humans, has been extremely difficult to accomplish. Some of the most disappointing results were in canine recipients, who initially showed signs of excellent isograft function with complete normalization of blood glucose levels, only to relapse after an interval of about 2 years.7

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References

  1. Lacy PE, Davie JM, Finke EH. Prolongation of islet allograft survival following in vitro culture [24°C] and a single injection of ALS. Science 1979; 204: 312.

    Article  PubMed  CAS  Google Scholar 

  2. Faustman D, Hauptfeld V, Lacy P et al. Demonstration of active tolerance in maintenance of established Islet of Langerhans allografts. Proc Natl Acad Sc USA 1982; 79: 4153.

    Article  CAS  Google Scholar 

  3. Selawry HP, Whittington K. Extended allograft survival of islets grafted into intra-abdominally placed testis. Diabetes 1984; 33: 405.

    Article  PubMed  CAS  Google Scholar 

  4. Tze WJ, Tai J. Successful intracerebral allotransplantation of pancreatic endocrine cells in spontaneous diabetic BB rats without immunosuppression. Metabolism 1984; 33: 785.

    Article  PubMed  CAS  Google Scholar 

  5. Sullivan FP, Ricordi C, Hauptfeld V et al. Effect of low-temperature culture and site of transplantation on hamster islet xenograft survival (hamster to mouse). Transplantation 1987; 44: 465.

    Article  PubMed  CAS  Google Scholar 

  6. Eloy R, Haffen K, Kedinger M. Chick embryo pancreatic transplants reverse experimental diabetes of rats. J Clin Invest 1979; 64: 361.

    Article  PubMed  CAS  Google Scholar 

  7. Alejandro R, Cutfield RG, Shienvold FL et al. Natural history of intrahepatic canine islet cell autografts. J Clin Invest 1986; 78: 1339.

    Article  PubMed  CAS  Google Scholar 

  8. Scharp D, Alderson D, Kneteman NM. The effects of immunosuppression on islet transplant function in dogs. Transplant Proc 1987; 19: 952.

    PubMed  CAS  Google Scholar 

  9. Rooth P, Dawidson I, Lafferty K et al. Prevention of detrimental effect of cyclosporine A on vascular ingrowth of transplanted pancreatic islets with verapamil. Diabetes 1989; 38 (suppl 1): 202.

    PubMed  CAS  Google Scholar 

  10. Mehigan DG, Ball WR, Zudema GD et al. Disseminated intravascular coagulation and portal hypertension following pancreatic islet autotransplantation. Ann Surg 1980; 191: 287.

    Article  PubMed  CAS  Google Scholar 

  11. Lafferty KJ, Prowse SJ, Simeonovic CJ et al. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann Rev Immunol 1983; 1: 143.

    Article  CAS  Google Scholar 

  12. Hiller WF, Klempnauer J, Luck R et al. Progressive deterioration of endocrine function after intraportal but not kidney sub-capsular rat islet transplanattion. Diabetes 1991; 40: 134.

    Article  PubMed  CAS  Google Scholar 

  13. Cattral MS, Warnock GL, Evans MG et al. Transplantation of purified frozen/thawed canine pancreatic islet allografts with cyclosporine. Transplantation 1991; 52: 457.

    Article  PubMed  CAS  Google Scholar 

  14. Gruber SA. The case for local immunosuppression. Transplantation 1992; 54: 1.

    Article  PubMed  CAS  Google Scholar 

  15. Barker CF, Gillingham RE. Immunologically privileged sites. Adv Immunol 1977; 25: 1.

    Article  PubMed  CAS  Google Scholar 

  16. Greene HSN. Familial mammary tumors in the rabbit. IV. The evolution of autonomy in the course of tumor development as indicated by transplantation experiments. J Exp Med 1940; 71: 305.

    Article  PubMed  CAS  Google Scholar 

  17. Selawry HP, Whittington K. Extended allograft survival of islets grafted into intra-abdominally placed testis. Diabetes 1984; 33: 405.

    Article  PubMed  CAS  Google Scholar 

  18. Naji A, Silvers WK, Bellgrau D et al. Spontaneous diabetes in rats: destruction of islets prevented by immunological tolerance. Science 1981; 213: 1390.

    Article  PubMed  CAS  Google Scholar 

  19. Selawry H, Fajaco R, Whittington K. Intratesticular islet allografts in the spontaneously diabetic BB/W rat. Diabetes 1985; 34: 1019.

    Article  PubMed  CAS  Google Scholar 

  20. Bellgrau D, Naji A, Silvers WK et al. Spontaneous diabetes in BB rats: evidence for T-Sertoli Cells in Islet Transplantation: cell-dependent immune response defect. Diabetologia 1982; 23: 359.

    Article  PubMed  CAS  Google Scholar 

  21. Guttmann RD, Colle E, Michel F et al. Spontaneous diabetes mellitus syndrome in the rat. 11. T-lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. J Immunol 1983; 130: 1732.

    PubMed  CAS  Google Scholar 

  22. Selawry H, Fajaco R, Whittington K. Extended survival of incubated MHC-compatible islet isografts in the spontaneously diabetc BB/W rat. Diabetes 1987; 36: 1061.

    Article  PubMed  CAS  Google Scholar 

  23. Selawry HP, Whittington K, Bellgrau D. Abdominal, intratesticular islet-xenograft survival in rats. Diabetes 1989; 38 (suppl 1): 220.

    PubMed  Google Scholar 

  24. Kupiec-Weglinski JW, Filho MA, Strom TB et al. Sparing of suppressor cells: a critical action of cyclosporine. Transplantation 1984; 38: 97.

    Article  PubMed  CAS  Google Scholar 

  25. Beschorner WE, Namnoum JD, Hess AD. Immunopathology of rat thymus after cyclosporine A. Transplant Today 1986; 19: 1230.

    Google Scholar 

  26. Georgiou HM, Lagarde AC, Bellgrau D. T cell dysfunction in the diabetes prone BB rat: a role for thymic migrants that are not T cell precursors. J Exp Med 1988; 167: 132.

    Article  PubMed  CAS  Google Scholar 

  27. Bellgrau D, Selawry H. Cyclosporine-induced tolerance to intratesticular islet xenografts. Transplantation 1990; 50: 654.

    Article  PubMed  CAS  Google Scholar 

  28. Pelletier RM, Byers SW. The blood-testis barrier and Sertoli cell junctions: Structural considerations. Micros Res Tech 1992; 20: 3.

    Article  CAS  Google Scholar 

  29. Head JR, Neaves WB, Billingham RE. Reconsideration of the lymphatic drainage of the rat testis. Transplantation 1983; 35: 91.

    Article  PubMed  CAS  Google Scholar 

  30. Head JR, Neaves WB, Billingham RE. Immune privilege in the testis. I basic parameters of allograft survival. Transplantation 1983; 36: 423.

    Article  PubMed  CAS  Google Scholar 

  31. Ferguson J, Scothorne RJ. Further studies on the transplantation of isolated pancreatic islets. J Anat 1977; 124: 9.

    PubMed  CAS  Google Scholar 

  32. Head JR, Billingham RE. Immune privilege in the testis. II. Evaluation of potential local factors. Transplantation 1985; 40: 269.

    Article  PubMed  CAS  Google Scholar 

  33. Selawry H, Whittington K. Prolonged intratesticular allograft survival is not dependent on local steroidogenesis. Horm Metab Res 1988; 20: 562.

    Article  PubMed  CAS  Google Scholar 

  34. Cameron DF, Whittington K, Schultz, RE et al. Successful islet/abdominal testis transplantation does not require Leydig cells. Transplantation 1990; 50: 649.

    Article  PubMed  CAS  Google Scholar 

  35. Russell LD, Steinberger A. Sertoli cells in culture:Views from the perspectives of an in Vivoist and an in Vitroist. Biol Reprod 1989; 41: 571.

    Article  PubMed  CAS  Google Scholar 

  36. Selawry HP, Kotb M, Herrod HG et al. Production of factor, or factors, suppressing IL-2 production and T cell proliferation by Sertoli cell-enriched preparations. Transplantation 1991; 52: 846.

    Article  PubMed  CAS  Google Scholar 

  37. Means AR. Early effects of FSH upon testicular metabolism. Adv Exp Med Biol 1973; 36: 431.

    Article  PubMed  CAS  Google Scholar 

  38. Bacha P, Williams DP, Waters C et al. Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of diptheria toxin-related interleukin 2 fusion protein. J Exp Med 1988; 167: 612.

    Article  PubMed  CAS  Google Scholar 

  39. Wyatt CR, Law L, Magnuson JA et al. Suppression of lymphocyte proliferation by proteins secreted by cultured Sertoli cells. J Reprod Immunol 1988; 14: 27.

    Article  PubMed  CAS  Google Scholar 

  40. DeCesaris P, Filippini A, Cervelli C et al. Immunosuppressive molecules produced by Sertoli cells cultured in vitro: Biological effects on lymphocytes. Biochem Biophys Res Commun 1992; 186: 1639.

    Article  CAS  Google Scholar 

  41. Nikolova DB, Kancheva LS, Surneva MD et al. Species-specific effect of proteins secreted by cultured pre-pubertal rat Sertoli cells on natural killer cell activity. Immunopharm 1992; 23: 15.

    Article  CAS  Google Scholar 

  42. Selawry HP, Gaber O, Whittington K et al. Intratesticular islet allograft survival in the Rhesus monkey. Diabetes 1992; 41: 155A.

    Google Scholar 

  43. Skalli M, Avallet O, Vigier M et al. Opposite vectorial secretion of Insulin-like Growth Factor I and its binding proteins by pig Sertoli cells cultured in the bicameral chamber system. Endocrinol 1992; 131: 985.

    Article  CAS  Google Scholar 

  44. Selawry HP, Whittington K, Forster H. Intratesticular islet xenograft survival in relation to tissue cyclosporine levels. Am J Med Sci 1988; 31: 497.

    Article  Google Scholar 

  45. Martin DC. Malignancy in the cryptorchid testis. Urol Clin N Am 1982; 9: 371.

    CAS  Google Scholar 

  46. Selawry HP, Cameron DF. Sertoli cell-enriched fractions in successful islet transplantation. Cell Transplantation 1993; 2: 123.

    PubMed  CAS  Google Scholar 

  47. Selawry H, Whittington K, Forster H. Effects of islet grafts of MHC-compatible donors on glucose metabolism in the spontaneously diabetic BB/Wor rat. Diabetes Res Clin Pract 1988; 5: 295.

    Article  PubMed  CAS  Google Scholar 

  48. Margolis RN, Holup JJ, Selawry HP. Effects of intratesticular islet transplantation on hepatic glycogen metabolism in the rat. Diab Res Clin Practice 1986; 2: 291.

    Article  CAS  Google Scholar 

  49. Whittington KP, Solomon SS, Selawry HP. Islet allografts in the cryptorchid testes of spontaneously diabetic BB/Wor dp rats: Response to glucose, glipizide, and arginine. Endocrinol 1991; 128: 2671.

    Google Scholar 

  50. Murray FT, Beyer-Mears A, Johnson RD et al. Assessment of proteinuria and neuropathy in the nonimmunosuppressed BB diabetic rat after abdominal intratesticular islet transplantation. Transplantation 1993; 56: 680.

    Article  PubMed  CAS  Google Scholar 

  51. Selawry HP, Pennel JP, Pardo V et al. The effects of culture-maintained pancreatic islets on metabolic parameters, renal function, and glomerular lesions in the diabetic rat. Metabolism 1980; 29: 261.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Helena P. Selawry
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© 1996 Springer-Verlag Berlin Heidelberg

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Selawry, H.P. (1996). Sertoli Cells in Islet Transplantation: Testicular Immune Privilege. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_19

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  • DOI: https://doi.org/10.1007/978-3-662-22105-1_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22107-5

  • Online ISBN: 978-3-662-22105-1

  • eBook Packages: Springer Book Archive

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