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Immunomodulation of Islet Allografts with Genetically Modified Muscle Cells

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Local Immunosuppression of Organ Transplants

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Localized perigraft delivery of immunosuppressive molecules can prolong islet allograft survival. This finding rests on three concepts: (1) immune recognition of an allograft can be modulated at the hostwwwwgraft interface; (2) immunosuppressive molecules can be delivered to the perigraft site by genetic engineering of carrier cells distinct from the islet allograft and (3) cotransplantation of genetically engineered myoblast carrier cells secreting immunosuppressive molecules with pancreatic islet cells can promote islet allograft survival.

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Authors
  1. Ming Yu
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  2. A. Alfred Chahine
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  3. Christian Stoeckert
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  4. Henry T. Lau
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© 1996 Springer-Verlag Berlin Heidelberg

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Yu, M., Chahine, A.A., Stoeckert, C., Lau, H.T. (1996). Immunomodulation of Islet Allografts with Genetically Modified Muscle Cells. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_18

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  • DOI: https://doi.org/10.1007/978-3-662-22105-1_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22107-5

  • Online ISBN: 978-3-662-22105-1

  • eBook Packages: Springer Book Archive

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