Abstract
The use of improved immunosuppression is responsible for the widespread application of organ transplantation. However, systemic immunosuppression frequently results in well-known, but unavoidable, side effects. Conversely, the phenomenon of transplant rejection has been recognized as a local cellular event, with extreme variability noted in rejection even between adjacent cells.1 Effective local immunosuppression by controlled-release drug delivery systems, such as polymer or biodegradable matrices, might be able to minimize immunosuppressive problems by delivering agents directly to the affected target cells, and optimal drug activity could be achieved with less systemic side effects.
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© 1996 Springer-Verlag Berlin Heidelberg
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Bolling, S.F., Labhasetwar, V., Levy, R.J. (1996). Controlled-Release Drug Matrices for Local Immunosuppression of Organ Transplants. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_16
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DOI: https://doi.org/10.1007/978-3-662-22105-1_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-22107-5
Online ISBN: 978-3-662-22105-1
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