Local Regulation of Allograft Rejection

  • Scott A. Gruber
  • Shengguang Xiao
  • Stephen E. Hughes
Part of the Medical Intelligence Unit book series (MIU.LANDES)


The rationale behind local immunosuppression is based on the following two hypotheses: first, that rejection can be effectively suppressed by controlling only those immunologic events occurring at the graft site and second, that by administering appropriately chosen immunosuppressive agents directly into the allograft, one can simultaneously prevent rejection and diminish or eliminate the drug-specific and general adverse consequences of systemic immunosuppression. The second hypothesis is addressed by the studies contained within the remaining sections of the book, which employ a variety of drug-targeting systems for achieving local immunosuppression. This chapter will review the available data in support of the first hypothesis by detailing the evidence for and the mechanisms of local regulation of allograft rejection.


Allograft Rejection Renal Allograft Cardiac Allograft Graft Site Limit Dilution Analysis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Scott A. Gruber
  • Shengguang Xiao
  • Stephen E. Hughes

There are no affiliations available

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