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Local Regulation of Allograft Rejection

  • Chapter
Local Immunosuppression of Organ Transplants

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

The rationale behind local immunosuppression is based on the following two hypotheses: first, that rejection can be effectively suppressed by controlling only those immunologic events occurring at the graft site and second, that by administering appropriately chosen immunosuppressive agents directly into the allograft, one can simultaneously prevent rejection and diminish or eliminate the drug-specific and general adverse consequences of systemic immunosuppression. The second hypothesis is addressed by the studies contained within the remaining sections of the book, which employ a variety of drug-targeting systems for achieving local immunosuppression. This chapter will review the available data in support of the first hypothesis by detailing the evidence for and the mechanisms of local regulation of allograft rejection.

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Authors
  1. Scott A. Gruber
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  2. Shengguang Xiao
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  3. Stephen E. Hughes
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© 1996 Springer-Verlag Berlin Heidelberg

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Gruber, S.A., Xiao, S., Hughes, S.E. (1996). Local Regulation of Allograft Rejection. In: Local Immunosuppression of Organ Transplants. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22105-1_1

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  • DOI: https://doi.org/10.1007/978-3-662-22105-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-22107-5

  • Online ISBN: 978-3-662-22105-1

  • eBook Packages: Springer Book Archive

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