STFs: STAT-Containing Transcription Factors
The term signal transducing factor (STF) was coined recently257,259 to draw together an apparently diverse group of transcription factor complexes which are elicited following stimulation of cytokine receptors and PTK receptors.257 These STFs were originally revealed by dint of their ability to bind to specific DNA elements (known as STAT-binding elements or SBEs; see below), as demonstrated by electrophoretic mobility shift assays (EMSAs). Although ach distinct cytokine evoked a particular STF, the composition of all of these STFs possessed a common theme, including the reactivity of some of the protein components with antiphosphotyrosine antibodies and the presence of STAT1 or a cross-reacting protein. Given the likely involvement of members of the STAT family of transcription factors in the cytokine-induced generation of transcription factor complexes such as these, it seems plausible that STFs are a functional manifestation of specific STAT-containing transcription complexes.
KeywordsTyrosine Polypeptide Interferon Resi Phosphotyrosine
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