Role of GTP-Binding Proteins in FcεRI Signaling

  • Anna Koffer
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Direct evidence for the involvement of specific GTPases in the response of mast cells or the related rat basophilic leukemia (RBL-2H3) cells to FcεRI activation is limited. However, several lines of circumstantial evidence point to the crucial role of GTP-binding proteins in the response of mast or RBL-2H3 cells to FcεRI activation. These include the effects of GTP depletion, of inhibition of the isoprenoid pathway and of various inhibitors and stimulators of GTP-binding proteins. Such experiments will be described in the first section of this chapter. Due to my interest in the mechanism of exocytosis, this and the last section are biased towards the secretory responses to activation of FcεRI and of GTP-binding proteins.


Mast Cell Guanine Nucleotide Guanine Nucleotide Exchange Factor FceRI Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1997

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  • Anna Koffer

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