The Structural Basis of the Interaction of IgE and FcεRI

  • Lin Rigby
  • Mark D. Hulett
  • Ross I. Brinkworth
  • P. Mark Hogarth
Part of the Molecular Biology Intelligence Unit book series (MBIU)


FcεRI is capable of inducing one of the most powerful and violent pharmacological responses known. Indeed the association of IgE with FcεRI, and subsequent aggregation is a most important interaction in the induction of human disease, and causes more chronic misery (in the West at least) than the engagement of any other immunological receptor. As approximately one in five people are afflicted with IgE dependent allergies—most notably allergic rhinitis or ‘hay fever’ and asthma—there has been a large effort made by many groups in studying this receptor, its ligand and the consequences of its activation. The impetus to study this receptor probably stems from its pathological role rather than its physiological one, which is still somewhat undefined, but with evidence pointing to an anti-parasite role.1


Mast Disulphide Papain Disul Gly2 


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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Lin Rigby
  • Mark D. Hulett
  • Ross I. Brinkworth
  • P. Mark Hogarth

There are no affiliations available

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