Abstract
The clinical importance of ex vivo human antibody production against cancer cells, infectious agents and many other key antigens has presented a major challenge for many years and has been addressed with great difficulty, due to the complex multicellular interactions underlining the humoral response.
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References
Mosier DE, Gulizia RJ, Torbett BE et al. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335: 256–59.
Vandekerckhove BA, Jones D, Punnonen J et al. Human Ig production and isotype switching in severe combined immunodeficient-human mice. J Immunol 1993; 151: 128–37.
Mosier DE. Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphoma genesis, and AIDS. Adv Immunol 1991; 50: 303–25.
Markham RB, Donnenberg AD. Effect of donor and recipient immunization protocols on primary and secondary human antibody responses in SCID mice reconstituted with human peripheral blood mononuclear cells. Infect Immun 1992; 60: 2305–08.
Sandhu J, Shpitz B, Gallinger S et al. Human primary immune response in SCID mice engrafted with human peripheral blood lymphocytes. J Immunol 1994; 152: 3806–13.
Lubin I, Segall H, Marcus H et al. Engraftment of human peripheral blood lymphocytes in normal strains of mice. Blood 1994; 83: 2368–81.
Marcus H, David M, Allon Canaan et al. Memory and primary humoral responses in human/Balb chimera. 1995; In Press.
Lubin I, Faktorowich Y, Lapidot T et al. Engraftment and development of human T and B cells in normal mice following bone marrow transplantation. Science 1991; 252: 427–31.
Lubin I, Segall H, Erlich P et al. Conversion of normal rats into SCIDlike animals following transplantation of murine SCID hone marrow allows engraftment of human peripheral blood lymphocytes. 35th Annual Meeting of the American Society of Hematology, St. Louis, Missouri, December 3–7, 1993.
Kulova L, Denis L, Lubin I et al. Natural antibodies do not prevent the engraftment of human peripheral blood lymphocytes in mice conditioned with supralethal doses of irradiation. Ref: Xenotransplant, In Press.
Hoffmann-Fezer G, Kranz B, Gall C et al. Peritoneal sanctuary for human lymphopoiesis in SCID mice injected with human peripheral blood lymphocytes from Epstein-Barr virus-negative donors. Eur J Immunol 1992; 22: 3161–66.
Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 1988; 242: 1706–09.
Duchosal MA, Eming SA, Fischer P et al. Immunization of hu-PBL-SCID mice and the rescue of human monoclonal Fab fragments through combinatorial libraries. Nature 1992; 355: 258–62.
Picchio GR, Kobayashi R, Kirven M et al. Heterogeneity among Epstein-Barr virus-seropositive donors in the generation of immunoblastic B-cell lymphomas in SCID mice receiving human peripheral blood leukocyte grafts. Cancer Res 1992; 52: 2468–77.
Hoffmann-Fezer G, Gall C, Zengerle U et al. Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice. Blood 1993; 81: 3440–48.
Nadel D, Albini B, Schlapfer E et al. Role of Epstein-Barr virus and interleukin 6 in the development of lymphomas of human origin in SCID mice engrafted with human tonsillar mononuclear cells. J Gen Virol 1992; 73: 113–21.
Pirruccello SJ, Nakamine H, Beisel KW et al. Hemagglutination and graftversus-host disease in the severe combined immunodeficiency mouse lympho-proliferative disease model. Am J Pathol 1992; 140: 1187–94.
Tary-Lehmann M, Saxon A. Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med 1992; 175: 503–16.
Mosier DE, Gulizia RJ, MacIsaac PD et al. Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160. Proc Natl Acad Sci USA 1993; 90: 2443–47.
Neil GA, Sammons DW. Immunization of SCID-hu mice and generation of anti-hepatitis B surface antigen-specific hybridomas by electrofusion. Hum Antibodies Hybridomas 1992; 3: 201–05.
Leader KA, Macht LM, Steers F et al. Antibody responses to the blood group antigen D in SCID mice reconstituted with human blood mononuclear cells. Immunology 1992; 76: 229–34.
Kumpel BM, Poole GD, Jackson DJ. Specific anti-responses of SCID mice populated with human lymphoid cells from peripheral blood, umbilical cord, bone marrow and spleen after immunization with group A erythrocytes. Immunol Lett 1992; 33: 163–8.
Nonoyama S, Smith F, Ochs H. Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes. J Immunol 1993; 151: 3894–901.
Abedi MR, Christensson B, Islam KB et al. Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cells. Eur J Immunol 1992; 22: 823–28.
Mazingue C, Cottrez F, Auriault C et al. Obtention of a human primary humoral response against schistosome protective antigens in severe combined immunodeficiency mice after the transfer of human peripheral blood mononuclear cells. Eur J Immunol 1991; 21: 1763–66.
Spiegelberg H, Beck L, Kocher H et al. Role of interleukin-4 in human immunoglobulin E formation in hu-PBL-SCID mice. J Clin Invest 1994; 93: 711–17.
Marcus H, Baracova T, Shtsen E et al. Human/BALB radiation chimera do not develop EBV lymphoma. 36th Annual Meeting of the American Society of Hematology, Nashville, Tennessee, December 2–6, Blood 1994; 84 (10): 447a.
Segall H, Lubin I, Erlich P et al. Adoptive transfer of functional human T cells into BALB/c mice. 35th Annual Meeting of the American Society of Hematology, St. Louis, Missouri, December 3–7, Blood 1993; 82 (10): 520a.
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© 1995 Springer-Verlag Berlin Heidelberg
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Reisner, Y. (1995). Antigen-Specific Immune Responses in Human/Mouse Chimeras. In: Human Hematopoiesis in SCID Mice. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-22008-5_6
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DOI: https://doi.org/10.1007/978-3-662-22008-5_6
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