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Glycoproteins and Cell Adhesion Functions

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Glycoproteins and Human Disease

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Oligosaccharide structures of glycoproteins differ between species, organs and cell types and are associated with a wide range of biological functions. Glycosylation patterns often fluctuate during growth, development and differentiation. The role of carbohydrate has been studied following the removal or modifications of carbohydrate by enzymic or chemical methods such as: with lectins and anticarbohydrate antibodies, by inhibition of certain steps in the biosynthetic pathways, by the use of mutant cell lines lacking enzymes involved in carbohydrate processing, by the introduction of genes or knocking out of genes or mRNA coding for glycosyltransferases, or by the expression of mammalian glycoproteins in systems differing in glycosylation.

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  1. Department of Biochemistry, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Inka Brockhausen Ph.D. & William Kuhns M.S., M.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Brockhausen, I., Kuhns, W. (1997). Glycoproteins and Cell Adhesion Functions. In: Glycoproteins and Human Disease. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21960-7_9

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