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Biosynthesis of N-Glycans

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Glycoproteins and Human Disease

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

The initial steps in the biosynthesis of N-glycans have been are preserved throughout evolution and are similar in lower and higher species. In contrast to O-glycans, N-glycans are pre-assembled as a dolicholpyrophosphate-(Dol-P-P-) intermediate and then transferred to protein by the action of oligosaccharyltransferase in the ER. Subsequent processing includes the trimming of Glc and Man residues and the addition of various sugars by Golgi glycosyltransferases (Fig. 3).

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  1. Department of Biochemistry, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Inka Brockhausen Ph.D. & William Kuhns M.S., M.D.

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Brockhausen, I., Kuhns, W. (1997). Biosynthesis of N-Glycans. In: Glycoproteins and Human Disease. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21960-7_6

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  • DOI: https://doi.org/10.1007/978-3-662-21960-7_6

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