Structures of β-N-Acetylglucosamine-Asn-Linked Oligosaccharides (N- Glycans)

  • Inka Brockhausen
  • William Kuhns
Part of the Medical Intelligence Unit book series (MIU.LANDES)


N-glycans are common on soluble and membrane bound glycoproteins and are often cell-, tissue-, and species-specific and may vary among different glycoproteins synthesized in the same cell, and between glycosylation sites of the same protein.


Sialic Acid Heparan Sulfate Proteoglycan Glycoprotein Hormone High Mannose GlcNAc Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hoogewerf AJ, Cisar LA, Evans DC et al. Effect of chlorate on the sulfation of lipoprotein lipase and heparan sulfate proteoglycans. Sulfation of heparan sulfate proteoglycans affects lipoprotein lipase degradation. J Biol Chem 1991; 266: 16564–16571.PubMedGoogle Scholar
  2. 2.
    Green E, Morishima C, Boime I et al. Structural requirements for sulfation of asparagine linked oligosaccharides of lutropin. Proc Natl Acad Sci USA 1985; 82: 7850–7854.PubMedCrossRefGoogle Scholar
  3. 3.
    Kato Y, Spiro R. Characterization of a thyroid sulfotransferase responsible for the 30-sulfation of terminal 3-D-galactosyl residues in N-linked carbohydrate units. J Biol Chem 1989; 264: 3364–3371.PubMedGoogle Scholar
  4. 4.
    Waard P, Koorevaar A, Kamerling J et al. Structure determination by H NMR spectroscopy of sulfated sialylated N-linked carbohydrate chains released from porcine thyroglobulin by peptide-N4-(N-acetyl -ßglucosylaminyl) asparagine Amidase-F*. J Biol Chem 1991; 266: 4237–4243.PubMedGoogle Scholar
  5. 5.
    Pfeiffer G, Strube K, Geyer R. Biosynthesis of sulfated glycoprotein N-glycans present in recombinant human tissue plasminogen activator. Biochem Biophys Res Comm 1992; 189: 1681–1685.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Inka Brockhausen
    • 1
  • William Kuhns
    • 1
  1. 1.Department of Biochemistry, Research Institute, Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

Personalised recommendations