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Inflammatory Diseases

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Glycoproteins and Human Disease

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Inflammation may be acute or chronic, and may occur as a primary event or secondary to another disease process. Common to all forms of inflammation is endothelial injury followed by recruitment of phagocytes and immunocytes. Carbohydrates are key to the ensuing cellular response. Sialyl-Lex has been recognized as a critical cell surface ligand in inflammatory reactions since it can bind to selectins that participate in early leukocyte-endothelial interactions1 and may also participate in integrin-mediated interactions. E-selectin is induced on endothelial cells in a variety of acute inflammatory conditions such as tonsillitis, appendicitis and delayed hypersensitivity reactions and its appearance correlates with the extravasation of neutrophils. P-selectin is expressed in Grave’s disease and rheumatoid arthritits.

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Authors and Affiliations

  1. Department of Biochemistry, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Inka Brockhausen Ph.D. & William Kuhns M.S., M.D.

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  1. Inka Brockhausen Ph.D.
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  2. William Kuhns M.S., M.D.
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© 1997 Springer-Verlag Berlin Heidelberg

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Brockhausen, I., Kuhns, W. (1997). Inflammatory Diseases. In: Glycoproteins and Human Disease. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21960-7_15

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  • DOI: https://doi.org/10.1007/978-3-662-21960-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21962-1

  • Online ISBN: 978-3-662-21960-7

  • eBook Packages: Springer Book Archive

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