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General Glycoprotein Functions

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Glycoproteins and Human Disease

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

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Abstract

Mucins are the major glycoprotein components of mucous secretions; they may also occur on cell membranes; the peptide backbone typically has highly O-glycosylated tandem repeat sequences and Cys rich amino and carboxyl-terminal ends that may polymerize to form long thread-like molecules of several million molecular weight. Mucins are produced and secreted by goblet cells, specialized epithelial cells which can store and condense mucin in secretory vesicles. Human MUC mucin genes encode mucin core proteins which are variably expressed and glycosylated in different tissues.1–4

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  1. Department of Biochemistry, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

    Inka Brockhausen Ph.D. & William Kuhns M.S., M.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Brockhausen, I., Kuhns, W. (1997). General Glycoprotein Functions. In: Glycoproteins and Human Disease. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21960-7_12

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  • DOI: https://doi.org/10.1007/978-3-662-21960-7_12

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