Abstract

  • Inka Brockhausen
  • William Kuhns
Part of the Medical Intelligence Unit book series (MIU.LANDES)

Abstract

Glycoproteins are widely distributed among different species, cell types and tissues. The sugar moieties of mammalian glycoproteins show significant changes in their structures and relative occurrences during growth, development and differentiation and have been implicated in many biological functions. Diverse alterations of these carbohydrate chains occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex alterations of oligosaccharide assembly by glycosyltransferases, mainly in the Golgi apparatus. These alterations affect early, intermediate and mainly late glycoprotein processing steps, depending on the disease type. Knowledge of the biological functions of glycoproteins and control mechanisms in the biosynthesis of glycans is instrumental for the development of better diagnosis and treatment and the understanding of the glycobiology of human disease.

Keywords

Sugar Carbohydrate Leukemia Oligosaccharide Glyco 

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Inka Brockhausen
    • 1
  • William Kuhns
    • 1
  1. 1.Department of Biochemistry, Research Institute, Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

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