Zusammenfassung
Ausgangspunkt aller Erkenntnisse über die Regeln und über die molekularen Mechanismen der Vererbung sowie über die Umsetzung von erblicher Information in Stoffwechselfunktionen ist die Variabilität von Merkmalen. Diese Variabilität erst gestattet es uns, bestimmte biologische Eigenschaften und Prozesse auf ihre Ursachen hin zu untersuchen.
An Malaria erkranktes Mädchen an der thailändischen Grenze. Mutationen können Resistenz verleihen. (Photo: P. Charlesworth, JB Pictures, New York)
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Auerbach C (1962) Mutation, an introduction to research on mutagenesis. Oliver und Boyd, Edinburgh
Nickoloff Ja, Hoekstra MF (eds) (1998) DNA damage and repair, vol 1 and 2, Humana Press, Totowa, NJ
Vries H de (1901) Die Mutationstheorie. Bd I. Veit, Leipzig
Ames BW (1979) Identifying environmental chemicals causing mutations and cancer. Science 204: 587–593
Ames BW, Durston WE, Yamasaki E, Lee FD (1973) Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 70: 2381–2385
Bonhoeffer F, Schaller H (1965) A method for selective enrichment of mutants based on the high ultraviolett sensitivity of DNA containing 5-bromouracil. Biochem Biophys Res Comm 20: 93–97
Bossi L, Smith D (1981) Suppressor sufj: a novel type of tRNA mutant that induces translational frameshifting. Proc Natl Acad Sci USA 81: 6105–6109
Brody S, Yanofsky C (1963) Suppressor gene alteration of protein primary structure. Proc Natl Acad Sci USA 50: 9–16
Carrano AV, Thompson LH, Lindl PA, Minkler JL (1978) Sister chromatid exchanges as an indication of muta-genesis. Nature 271, 551–553
Cleaver JE, Kraemer KH (1989) Xeroderma pigmentosum. In: Scriver CA, Beaudet AL, Sly WS, Vale D (eds) The metabolic basis of inherited disease, 6th edn. McGraw-Hill, New York, pp 2949–2971
Dustin P (1978) Microtubules. Springer, Berlin Heidelberg New York Tokyo
Friedberg EC (1992) Xeroderma pigmentosum, Cockayne’s syndrome, helicases, and DNA repair: What’s the relationship. Cell 71: 887–889
Fu Y-H, Pizzuti A, Fenwick RG Jr et al. (1992) An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science 255: 1256–1258
Grosveld F, van Assendelft GB, Greaves DR, Kollias G (1987) Position-independent, high-level expression of the human 13-globin genes in transgenic mice. Cell 51: 975–985
Heidelberger C (1975) Molecular mechanisms of mutation. Ann Rev Biochem 44: 79–121
Hook EB, Lindsjö A (1978) Am J Hum Genet 30: 19
Johnston LH (1979) Nuclear mutations in Saccharomyces cerevisiae which increase the spontaneous mutation frequency in mitochondrial DNA. Mol Gen Genet 170: 327–331
Kiss A (1966) Neue Richtung in der Triticale-Züchtung. Z Pflanzenzüchtung 55: 309–329
Kremer EJ, Pritchard M, Lynch M et al. (1991) Mapping of DNA instability at the fragile X to a trinucleotide repeat sequence p(CCG),,. Science 252: 1711–1714
La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH (1991) Androgen receptor gene mutations in X-linked spinal and bulbar muscular dystrophy. Nature 352: 77–79
de Laat WL, Jaspers NGJ, Hoeijmakers JHJ (1999) Molecular mechanisms of nucleotide excision repair. Genes und Development 13: 768–785
Luria SE, Delbrück M (1943) Mutations in bacteria from virus sensitivity to virus resistance. Genetics 28: 491–502
McFadden ES, Sears ER (1946) The origin of Triticum spelta and its free-threshing hexaploid relatives. J Hered 37: 107–116
Morris R, Sears ER (1967) In: Quisenberry KS, Reitz LP (eds) Wheat and wheat improvement. Am Soc Agron, Madison, Wisconsin, pp 19
Mounkes LC, Jones RS, Liang BC, Gelbart W, Fuller MT (1992) A Drosophila model for Xeroderma pigmentosum and Cockayne’s syndrome: haywire encodes the fly homolog of ERCC3, a human excision repair gene. Cell 71: 925–937
Nussbaum RL, Ledbetter DH (1986) Fragile X syndrome: A unique mutation in man. Ann Rev Genet 20: 109–145
Rabbits TH (1991) Translocations, master genes, and differences between the origins of acute and chronic leukemias. Cell 67: 641–644
Rathmell WK, Chu G (1998) Mechanisms for DNA double-stranded break repair in eukaryotes In: Nickoloff JA, Hoekstra MF (eds) DNA damage and repair, vol 2: DNA Repair in Higher Eukaryotes, Humana Press, Totowa, NJ, pp 299–316
Richards RI, Sutherland GR (1992) Dynamic mutations: A new class of mutations causing human disease. Cell 70: 709–712
Rossi HH, Kellerer AM (1974) Radiat Res 58: 131–140 Sears ER (1948) The cytology and genetics of wheats and their relatives. Adv Genetics 2, 240–270
Sears ER (1959) In: Kappert H, Rudorf W (ed) Handbuch der Pflanzenzüchtung, Bd 2. Parey, Berlin
Troelstra C, van Gool A, de Wit J, Vermeulen W, Bootsma D, Hoejimakers JHJ (1992) ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne’s syndrome and preferential repair of active genes. Cell 71: 939–953
Wolfe KH, Li W-H, Sharp PM (1987) Rates of nucleotide substitutions vary greatly among plant mitochondrial, chloroplast, and nuclear DNA. Proc Natl Acad Sci USA 84: 9054–9058
Wolfe KH, Sharp PM, Li W-H (1989) Rates of synonymous substitution in plant nuclear genes. J Mol Evol 29: 208–211
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hennig, W. (2002). Veränderungen von Genen: Mutationen. In: Genetik. Springer-Lehrbuch. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21953-9_14
Download citation
DOI: https://doi.org/10.1007/978-3-662-21953-9_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-21954-6
Online ISBN: 978-3-662-21953-9
eBook Packages: Springer Book Archive