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Progression of Medullary Thyroid Carcinoma

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Genetic Mechanisms in Multiple Endocrine Neoplasia Type 2

Part of the book series: Medical Intelligence Unit ((MIU.LANDES))

Abstract

Auniversal aspect of cancer development is its multistage nature. Precancerous stages evolve to more advanced stages of malignancy and metastasis. This has been reviewed extensively by Foulds.1,2 Based on observations of karyotypic progression in hematopoietic and other neoplasms, Nowell3 proposed a clonal evolution model for tumor progression. In this model, variant cell clones which possess some growth advantage overgrow the other cells in the tumor.

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  1. Barry D. Nelkin
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© 1996 Springer-Verlag Berlin Heidelberg

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Nelkin, B.D. (1996). Progression of Medullary Thyroid Carcinoma. In: Genetic Mechanisms in Multiple Endocrine Neoplasia Type 2. Medical Intelligence Unit. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-21948-5_8

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  • DOI: https://doi.org/10.1007/978-3-662-21948-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21950-8

  • Online ISBN: 978-3-662-21948-5

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