Part of the Medical Intelligence Unit book series (MIU.LANDES)


The preceding chapters establish a framework to answer basic questions about the biology of MEN 2; the resulting knowledge will undoubtedly provide new therapeutic targets for MTC, pheochromocytoma and biologically related cancers. Here, I would like to point out some of the questions which have been raised in the text, and which seem to me to be of special interest for future study. Of course, these choices reflect my bias; and others might emphasize alternate lines of investigation.


Neural Crest Multiple Endocrine Neoplasia Type Neural Crest Cell Human Small Cell Lung Cancer Adrenal Medullary Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Mabry M, Nakagawa T, Nelkin BD et al. Viral Harvey as oncogene insertion: a model for tumor progression of human small cell lung cancer. Proc Natl Acad Sci USA 1988; 85: 6523–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Conrad KE, Gutierrez-Hartmann A. The ras and protein kinase A pathways are mutually antagonistic in regulating rat prolactin promoter activity. Oncogene 1992; 7: 1279–86.PubMedGoogle Scholar
  3. 3.
    Celano P, Berchtold CM, Mabry M et al. Induction of markers of normal differentiation in human colon carcinoma cells by the vrasH oncogene. Cell Growth Diff 1993; 4: 341–7.PubMedGoogle Scholar
  4. 4.
    Dietrich WF, Lander ES, Smith JS et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 1993; 75: 631–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Schulz N, Propst F, Rosenberg MP et al. Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: A model for the human multiple endocrine neoplasia type 2 syndrome. Cancer Res 1992; 52: 450–5.PubMedGoogle Scholar
  6. 6.
    Schuchardt A, D’Agati V, Larsson-Blomberg L et al. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 1994; 367: 380–3.PubMedCrossRefGoogle Scholar
  7. 7.
    Lorenzo MJ, Eng C, Mulligan LM et al. Multiple mRNA isoforms of the human RET proto-oncogene generated by alternate splicing. Oncogene 1995; 10: 1377–83.PubMedGoogle Scholar
  8. 8.
    Fontaine J. Multistep migration of calcitonin cell precursors during ontogeny of the mouse pharynx. Gen Comp Endocrin 1979; 37: 81–92.CrossRefGoogle Scholar
  9. 9.
    DeLellis RA. The pathology of medullary thyroid carcinoma and its precursors. In: LiVolsi VA, DeLellis RA, eds. Pathology of the Parathyroid and Thyroid Glands. Baltimore: Williams and Wilkins, 1993: 72–102.Google Scholar

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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  1. 1.Johns Hopkins Oncology Center, School of MedicineJohns Hopkins UniversityBaltimoreUSA

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