The research focused on “mechanisms of carcinogenesis” is concerned with the fundamental question as to how and why cancer arises. The research projects grouped together here thus have a common concept. Despite all diversity of the experimental approaches, this concept can be described as follows: Model reconstruction of the transformation of a normal cell into a cancer cell under deliberately chosen conditions which allow as complete as possible an observation of the molecular processes leading to cancer development. Experimentation with cancer-inducing rays, chemical carcinogens as well as tumor viruses are in principle equivalent. It is indeed appropriate to experiment with different agents, since cancer is not caused by a single factor but by many causes, and this must be borne in mind in experimentation.
KeywordsPhenol Leukemia Hydrocarbon Adenosine Electrophoresis
Unable to display preview. Download preview PDF.
- Jones, E. G., Mac Donald, I., Breslow, L.: Study of epidemiologic factors in carcinoma of uteri cervix. Amer. J. Obstet Gynecol. 76, 1–10 (1958).Google Scholar
- Report of the Surgeon General, Washington. Cancer Incidence in Five Continents Vol. 4 (IARC) (1982).Google Scholar
- Gissmann, L.: Papillomaviruses and their association with cancer in animals and in man. Cancer Surveys 3, 161–181 (1984).Google Scholar
- Vonka, W., Kanka, J., Jelinek, J., Subrt, I., Suchanek, A., Havrankova, A., Vachal, M., Hirsch, I., Domarazkova, E., Zavadova, H., Richterova, V., Naprstkova, I., Dvorakova, V., Svoboda, B.: Prospective study on the relationship between cervical neoplasia and Herpes Simplex Type-2 Virus. I. Epidemiological characteristics. Int. J. Cancer 33, 49–60 (1984).PubMedCrossRefGoogle Scholar
- Gissmann, L., Schwarz, E., Cloning of papillomavirus DNA. In: Developments in molecular virology, Vol. 5, Recombinant DNA pp 173–197. Y. Becker (ed.) Martinus Nijhoff, Publishers, Hingham, Ma. (1985).Google Scholar
- Seedorf, K., Krämmer, G., Dürst, M., Suhai, S., Röwekamp, W. G.: Human papillomvirus type 16 DNA sequence. Virology 144 (1985).Google Scholar
- Seedorf, K., Krämmer, G., Röwekamp, W. G.: Human Papilloma Virus Type 16 DNA: Expression of open reading frames in E coli.Google Scholar
- Howley, P. M., and Broker, T. R. (ed.) in Papilloma Viruses, Molecular and Clinical Aspects, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 32, 1985.Google Scholar
- Cohen, S. A., Salazar, D., Nolan, J. P.: Natural cytotoxicity of isolated rat liver cells. J. Immunology 129, 495–501 (1982).Google Scholar
- Burkart, V., Malter, M., Süss, R., Friedrich, E.: Liver as a tumor cell killing organ: Immunol. Comm. 13, 77–81 (1984).Google Scholar