Mechanisms of Carcinogenesis

  • Lutz Gissmann
  • Günter Krämmer
  • Rudolf Süss
  • Margarete Malter


The research focused on “mechanisms of carcinogenesis” is concerned with the fundamental question as to how and why cancer arises. The research projects grouped together here thus have a common concept. Despite all diversity of the experimental approaches, this concept can be described as follows: Model reconstruction of the transformation of a normal cell into a cancer cell under deliberately chosen conditions which allow as complete as possible an observation of the molecular processes leading to cancer development. Experimentation with cancer-inducing rays, chemical carcinogens as well as tumor viruses are in principle equivalent. It is indeed appropriate to experiment with different agents, since cancer is not caused by a single factor but by many causes, and this must be borne in mind in experimentation.


Cervical Cancer Human Papilloma Virus Kupffer Cell Cervical Carcinoma Circulate Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Selected publications

  1. Jones, E. G., Mac Donald, I., Breslow, L.: Study of epidemiologic factors in carcinoma of uteri cervix. Amer. J. Obstet Gynecol. 76, 1–10 (1958).Google Scholar
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  3. Report of the Surgeon General, Washington. Cancer Incidence in Five Continents Vol. 4 (IARC) (1982).Google Scholar
  4. Gissmann, L., de Villiers, E. M., zur Hausen, H.: Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int. J. Cancer 29, 143–146 (1982).PubMedCrossRefGoogle Scholar
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  8. zur Hausen, H.: Herpes simplex virus in human genital cancer. Int. Rev. Exp. Pathol. 25, 307–325 (1983).PubMedGoogle Scholar
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  15. Dürst, M., Gissmann, L., Ikenberg, H., zur Hausen, H.: A papillomvirus DNA from a cervical carcinoma and its prelevance in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80, 3812–3815 (1983).PubMedCentralPubMedCrossRefGoogle Scholar
  16. Seedorf, K., Krämmer, G., Dürst, M., Suhai, S., Röwekamp, W. G.: Human papillomvirus type 16 DNA sequence. Virology 144 (1985).Google Scholar
  17. Seedorf, K., Krämmer, G., Röwekamp, W. G.: Human Papilloma Virus Type 16 DNA: Expression of open reading frames in E coli.Google Scholar
  18. Howley, P. M., and Broker, T. R. (ed.) in Papilloma Viruses, Molecular and Clinical Aspects, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 32, 1985.Google Scholar
  19. Cohen, S. A., Salazar, D., Nolan, J. P.: Natural cytotoxicity of isolated rat liver cells. J. Immunology 129, 495–501 (1982).Google Scholar
  20. Burkart, V., Friedrich, E.: Intravital microscopy of the perfused liver: RES 32, 269–272 (1982).PubMedGoogle Scholar
  21. Burkart, V., Malter, M., Süss, R., Friedrich, E.: Liver as a tumor cell killing organ: Immunol. Comm. 13, 77–81 (1984).Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Lutz Gissmann
    • 1
  • Günter Krämmer
    • 2
  • Rudolf Süss
    • 3
  • Margarete Malter
    • 3
  1. 1.Genome Modifications and CarcinogenesisInstitute of Virus ResearchGermany
  2. 2.Molecular Biology of the Cell IInstitute of Cell and Tumor BiologyGermany
  3. 3.Project Group Cancer EncyclopediaInstitute of Experimental PathologyGermany

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