Abstract
The research focused on “mechanisms of carcinogenesis” is concerned with the fundamental question as to how and why cancer arises. The research projects grouped together here thus have a common concept. Despite all diversity of the experimental approaches, this concept can be described as follows: Model reconstruction of the transformation of a normal cell into a cancer cell under deliberately chosen conditions which allow as complete as possible an observation of the molecular processes leading to cancer development. Experimentation with cancer-inducing rays, chemical carcinogens as well as tumor viruses are in principle equivalent. It is indeed appropriate to experiment with different agents, since cancer is not caused by a single factor but by many causes, and this must be borne in mind in experimentation.
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Jones, E. G., Mac Donald, I., Breslow, L.: Study of epidemiologic factors in carcinoma of uteri cervix. Amer. J. Obstet Gynecol. 76, 1–10 (1958).
zur Hausen, H.: Papillomaviruses and their possible role in squamous cell carcinoma. Curr. Top. Microbiol. Immunol. 78, 1–30 (1977).
Report of the Surgeon General, Washington. Cancer Incidence in Five Continents Vol. 4 (IARC) (1982).
Gissmann, L., de Villiers, E. M., zur Hausen, H.: Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int. J. Cancer 29, 143–146 (1982).
Crum, C. P., Lkenberg, H., Richart, R. M., Gissmann, L: Human papillomavirus type 16 and early cervical neoplasia. New Engl. J. Med. 310, 880–883 (1983).
Dürst, M., Gissmann, L., Ikenberg, H., zur Hausen, H.: A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsies from different geographic regions. Proc. Natl. Acad. Sci. USA 60, 3812–3815 (1983).
Gissmann, L., Wolnik, L., lkenberg, H., Koldovsky, U., Schnürch, H. G., zur Hausen, H.: Human Papillomavirus type 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancer. Proc. Natl. Acad. Sci. USA 80, 560–562 (1983).
zur Hausen, H.: Herpes simplex virus in human genital cancer. Int. Rev. Exp. Pathol. 25, 307–325 (1983).
Boshart, M., Gissmann, L., Lkenberg, H., Kleinheinz, A., Scheurlen, W., zur Hausen, H.: A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J. 3, 1151–1157 (1984).
Gissmann, L.: Papillomaviruses and their association with cancer in animals and in man. Cancer Surveys 3, 161–181 (1984).
Gissman, L., Boshart, M., Dürst, M., lkenberg, H., Wagner, D., zur Hausen, H.: Presence of human papillomavirus (HPV) DNA in genital tumors. J. Invest. Dermatol. 83, 26s-28s (1984).
lkenberg, H., Gissmann, L., Gross, G., GrußendorfConen, E.-I., zur Hausen, H.: Human papillomavirus type 16 related DNA in genital Bowen’s disease and in Bowenoid papulosis. Int. J. Cancer 32, 563–565 (1984).
Vonka, W., Kanka, J., Jelinek, J., Subrt, I., Suchanek, A., Havrankova, A., Vachal, M., Hirsch, I., Domarazkova, E., Zavadova, H., Richterova, V., Naprstkova, I., Dvorakova, V., Svoboda, B.: Prospective study on the relationship between cervical neoplasia and Herpes Simplex Type-2 Virus. I. Epidemiological characteristics. Int. J. Cancer 33, 49–60 (1984).
Gissmann, L., Schwarz, E., Cloning of papillomavirus DNA. In: Developments in molecular virology, Vol. 5, Recombinant DNA pp 173–197. Y. Becker (ed.) Martinus Nijhoff, Publishers, Hingham, Ma. (1985).
Dürst, M., Gissmann, L., Ikenberg, H., zur Hausen, H.: A papillomvirus DNA from a cervical carcinoma and its prelevance in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80, 3812–3815 (1983).
Seedorf, K., Krämmer, G., Dürst, M., Suhai, S., Röwekamp, W. G.: Human papillomvirus type 16 DNA sequence. Virology 144 (1985).
Seedorf, K., Krämmer, G., Röwekamp, W. G.: Human Papilloma Virus Type 16 DNA: Expression of open reading frames in E coli.
Howley, P. M., and Broker, T. R. (ed.) in Papilloma Viruses, Molecular and Clinical Aspects, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol. 32, 1985.
Cohen, S. A., Salazar, D., Nolan, J. P.: Natural cytotoxicity of isolated rat liver cells. J. Immunology 129, 495–501 (1982).
Burkart, V., Friedrich, E.: Intravital microscopy of the perfused liver: RES 32, 269–272 (1982).
Burkart, V., Malter, M., Süss, R., Friedrich, E.: Liver as a tumor cell killing organ: Immunol. Comm. 13, 77–81 (1984).
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© 1986 Springer-Verlag Berlin Heidelberg
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Gissmann, L., Krämmer, G., Süss, R., Malter, M. (1986). Mechanisms of Carcinogenesis. In: Current Cancer Research 1986. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-21737-5_4
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DOI: https://doi.org/10.1007/978-3-662-21737-5_4
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-7985-0712-8
Online ISBN: 978-3-662-21737-5
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