Localization of EF-Hand Ca2+-Binding Proteins in the CNS

  • Claus W. Heizmann
  • Katharina Braun
Part of the Neuroscience Intelligence Unit book series (NIU.LANDES)


The intention of this chapter is not to provide a complete review of all the anatomical literature dealing with the distribution of Ca2+-binding proteins in the central nervous system, rather an attempt is made to survey the distribution and cellular localization of Ca2+-binding proteins in selected brain systems of the mammalian brain. Special emphasis is placed on brain systems that are affected in certain neurodegenerative diseases of the human brain, such as hippocampus, cerebellum, basal ganglia and cortical areas. Since, for most of these brain regions, excellent, extensive, and very detailed descriptions of cell types, their distribution and pathways containing different Ca2+-binding proteins have already been published (for reviews see refs. 1–6), the following description is restricted to brain areas and their neurons and functional pathways, which are related to the pathology of brain diseases.


Purkinje Cell Pyramidal Neuron Zebra Finch Axon Initial Segment Local Circuit Neuron 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Claus W. Heizmann
    • 1
  • Katharina Braun
    • 2
  1. 1.University of ZurichZurichSwitzerland
  2. 2.Federal Institute for NeurobiologyMagdeburgGermany

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