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New Perspectives on Estrogen, Progesterone, and Oxytocin Action in Primate Parturition

  • Miles J. Novy
  • George J. Haluska
Conference paper
Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 7)

Abstract

In studying the control of parturition in primates it is logical to concentrate on those endocrine and paracrine regulators which have proven to be important prerequisites for parturition in other species (i.e., estrogens, progesterone, prostaglandins, oxytocin, and cytokines). It has been shown in domestic ruminants that increased estrogen levels and falling progesterone levels at term (dependent upon the fetal adrenal secretion of Cortisol) are pivotal for the initiation of parturition (Liggins et al. 1977; Challis and Olson 1988). Although the rising production of estrogens by the fetoplacental unit provides an attractive mechanism for the endocrine initiation of labor in primates, estrogens likely serve only a permissive function in parturition. There is no evidence for the lowering of progesterone concentrations in the maternal, fetal, or amniotic fluid compartments in higher primates prior to or during labor. However, a prepartum fall in progesterone is such a ubiquitous phenomenon across species that it is still tempting to search for evidence of a localized progesterone withdrawal mechanism in target tissues of primates. Indeed, the recent availability of effective antiprogestins has provided an efficient tool to facilitate such investigation.

Keywords

Rhesus Monkey Maternal Plasma Fetal Membrane Spontaneous Labor Cervical Ripening 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Miles J. Novy
  • George J. Haluska

There are no affiliations available

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