Modulation of Neutrophil Function in Sepsis

  • W. Karzai
  • K. Reinhart
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 2000)


The neutrophil plays a crucial role in host defense against microbial infections. Reductions in neutrophil numbers predispose the inflicted individuals to recurring and life-threatening bouts of infectious disease. In patients undergoing chemotherapy or in patients suffering from cyclic neutropenia, the incidence and prevalence of infections decrease with increasing numbers of neutrophils [1–3]. Furthermore, functional abnormalities of neutrophils such as deficiency of respiratory burst also lead to recurrent serious infections despite normal neutrophil counts [4].


Neutrophil Function Neutrophil Number Cyclic Neutropenia Chronic Neutropenia Increase Neutrophil Count 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • W. Karzai
  • K. Reinhart

There are no affiliations available

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