Heme Oxygenase and Acute Lung Injury: The Functional Significance of Heme Oxygenase Induction

  • N. J. Lamb
  • G. J. Quinlan
  • T. W. Evans
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1999)


In spite of major advances in intensive care, the morbidity and mortality of patients with acute respiratory distress syndrome (ARDS) remains high, and therapy is at best supportive [1, 2]. ARDS is characterized by refractory hypoxemia secondary to non-hydrostatic pulmonary edema [3] and is precipitated by a range of common predisposing factors not necessarily related to primary lung injury, such as polytrauma, severe burns, sepsis, gastric aspiration, surgery necessitating cardiopulmonary bypass (CPB), lung resection, hemorrhagic shock, and oxygen toxicity [4].


Acute Lung Injury Acute Respiratory Distress Syndrome Heme Oxygenase Pulmonary Artery Smooth Muscle Cell Heme Oxygenase Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • N. J. Lamb
  • G. J. Quinlan
  • T. W. Evans

There are no affiliations available

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