Volume Kinetics: A New Method to Optimize Fluid Therapy
Isotope techniques used to estimate the volume effect of fluid given by intravenous infusion poorly reflect changes over time, and also give erroneous figures for the size of the body fluid space that becomes expanded by the infused fluid. Volume kinetics is a new approach designed to overcome these problems by using pharmacokinetic modeling principles and simulation techniques. The kinetic models use repeated measurements of the dilution of plasma as an input variable, and are particularly useful to study the body’s handling of fluid given at high rates.
KeywordsPlasma Volume Total Body Water Fluid Therapy Elimination Rate Constant Evans Blue
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