Intestinal Epithelial Hyperpermeability

  • M. P. Fink
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1997)

Abstract

The gut serves not only as a portal of entry for nutrients, small ions, and water, but also as a selective barrier preventing systemic contamination by lumen-derived microbes or microbial products. A key component of the gastrointestinal barrier is the epithelium itself. There are only two ways that substances (ions, molecules, or particles) can traverse the epithelium from the lumenal compartment to the basolateral compartment. Permeation can occur via the transcellular pathway (i.e. through cells) or via the paracellular pathway (i.e. between cells).

Keywords

Ischemia Superoxide Glutamine NADPH Fibril 

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  • M. P. Fink

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