The Cytokine Response to Hemorrhagic Shock
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Although animals face many noxious and potentially lethal stimuli, the overall response to these insults tend to be conserved. Be it bacteria or blood loss, the final physiologic and cellular conditions are often remarkably similar. This occurs primarily due to the funneling of signals into common pathways. Cellular signaling both locally and remote to the site of an insult is usually facilitated via cytokines. Specific cytokines in this “warning/activation” system are frequently increased dramatically in response to injury. Often, a given cytokine affects the next molecule in the cascade, as one sees in sepsis. In addition, a large portion of this regulation occurs at the molecular level, with overexpression or suppression of specific products.
KeywordsTumor Necrosis Factor Abdominal Aortic Aneurysm Hemorrhagic Shock Bacterial Translocation Tumor Necrosis Factor Production
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- 4.Bellomo R (1992) The cytokine network in the critically ill. Anesthesia and Intensive Care 20: 288–302Google Scholar
- 12.Ertel W, Morrison MH, Ayala A, Chaudry IH (1994) Biological significance of elevated TNF levels: In vivo administration of monoclonal antibody against TNF following hemorrhagic shock increases the capacity of macrophages to release TNF while restoring immunoresponsiveness. Cytokine 6: 624–632PubMedCrossRefGoogle Scholar