Effects of Hemoglobin in Sepsis

  • S. R. Fischer
  • H. G. Bone
  • D. L. Traber
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1997)


Sepsis remains a major contributor to morbidity and mortality among the patient population of intensive care units [1]. Despite extensive research, treatment remains symptomatic and supportive. Clinically, sepsis in its hyperdynamic state is characterized by hypotension due to decreased systemic vascular resistance. The cardiac output is elevated in most cases of clinical sepsis. The vascular system is unresponsive to endogenous and exogenous catecholamines, myocardial contractility is decreased, and there is increased precapillary shunting manifesting itself as an increase in central venous oxygen saturation. As the syndrome worsens, a hypo-dynamic state follows, with circulatory shock and lactic acidosis secondary to tissue hypoxia, often leading to multiple organ dysfunction syndrome (MODS) and death.


Nitric Oxide Mean Arterial Pressure Renal Blood Flow Multiple Organ Dysfunction Syndrome Regional Blood Flow 
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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. R. Fischer
  • H. G. Bone
  • D. L. Traber

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