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Clinical Effects of Cell-Free Hemoglobin, a Scavenger of Nitric Oxide, in Septic Shock

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Yearbook of Intensive Care and Emergency Medicine 1997

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1997))

Abstract

Septic shock is characterized by fever, metabolic abnormalities, cardiovascular instability and multiple organ failure. The predominant physiological change that occurs in all septic shock patients is the loss of vascular tone. This in turn leads to hypotension and alterations in microvascular blood flow resulting in major organ dysfunction. It is important that alternatives be found to currently available vasopressor therapy for septic shock. Recent studies [1–3] have shown that doses of norepinephrine needed to achieve recommended physiological endpoints lead to increased mortality presumably through non-specific excessive vasoconstriction of critical vascular beds resulting in secondary organ failure.

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Authors
  1. R. G. Kilbourn
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  2. J. DeAngelo
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  3. J. Bonaventura
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1997 Springer-Verlag Berlin Heidelberg

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Kilbourn, R.G., DeAngelo, J., Bonaventura, J. (1997). Clinical Effects of Cell-Free Hemoglobin, a Scavenger of Nitric Oxide, in Septic Shock. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine, vol 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13450-4_22

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  • DOI: https://doi.org/10.1007/978-3-662-13450-4_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-13452-8

  • Online ISBN: 978-3-662-13450-4

  • eBook Packages: Springer Book Archive

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