Activation of Poly-(ADP-Ribose) Synthetase by Peroxynitrite

  • C. Szabó
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1997)


Over the last several decades, there has been a substantial body of work implicating the pathophysiological roles of oxygen-derived free radicals in various forms of circulatory shock [1, 2]. More recently, it became also evident that the free radical nitric oxide (NO) serves a number of physiological and pathophysiological functions in the body, wherein the expression of the inducible isoform of NO synthase (NOS) has been proposed as an important mediator of the cardiovascular failure in shock [3, 4].


Nitric Oxide Hemorrhagic Shock Endotoxic Shock Circulatory Shock Peroxynitrite Production 
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© Springer-Verlag Berlin Heidelberg 1997

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  • C. Szabó

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