Nitric Oxide: A Modulator of the Inflammation Response

  • P. Kubes
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1997)


Inflammatory intestinal disorders are characterized by leukocyte infiltration, increased microvascular permeability and mucosal barrier dysfunction. The latter is of major concern in the clinical setting since a breakdown of the mucosal barrier can lead to bacterial translocation and ultimately sepsis. The underlying mechanisms that contribute to the injury associated with the onset of inflammation include reactive oxygen metabolites, vasocongestion, pro-inflammatory mediators, leukocyte infiltration and mast cell reactivity [1]. A large amount of work has been performed in an attempt to identify pro-inflammatory molecules associated with pathophysiologic conditions of the intestine, but little has been done in terms of possible endogenous anti-inflammatory molecules that either dampen or even turn off the inflammatory process. There is a growing body of evidence that endogenous nitric oxide (NO) may serve this function particularly in the intestinal tract.


Nitric Oxide Mast Cell Leukocyte Adhesion Microvascular Permeability Epithelial Permeability 
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© Springer-Verlag Berlin Heidelberg 1997

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  • P. Kubes

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