Determinants of Outcome from Sepsis and Septic Shock

  • G. M. Wray
  • C. J. Hinds
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1997)


Septic shock is the most common cause of death in intensive care units (ICU) [1]. Between 1979 and 1987, “septicemia” was the 13th most frequent cause of all deaths in North America [2] and the incidence of sepsis continues to rise. Despite the strenuous efforts of scientists and clinical investigators neither improved resuscitation and supportive treatment, nor adjunctive therapy aimed at modulating the inflammatory response, has significantly influenced mortality, which has changed little since the 1970’s [3]. A greater understanding of the physiological variables which influence outcome from sepsis and septic shock may assist in attempts to improve survival by providing further insights into the underlying pathophysiology, guiding the development of new experimental models, indicating potentially valuable areas for further research and suggesting new therapies. Such information might also enable the clinician to identify those patients at greatest risk who may need early or more aggressive intervention and could be used to guide treatment at the bedside.


Septic Shock Mean Arterial Pressure Multiple Organ Dysfunction Syndrome Blood Lactate Level Sepsis Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • G. M. Wray
  • C. J. Hinds

There are no affiliations available

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