Apoptosis in the Resolution of Systemic Inflammation
- 93 Downloads
Admission to a contemporary ICU is precipitated by a heterogeneous group of disease processes, yet the final common pathway to death is strikingly similar . Fully 80% of all ICU deaths occur in association with the multiple organ dysfunction syndrome (MODS) , a poorly understood process characterized by the development of progressive physiologic dysfunction in organ systems initially unaffected by the primary disease process. Activation of a host inflammatory response by infection, injury, or ischemia, invariably proceeds the development of MODS . The proximate causes of organ injury are not bacterial products, but the same endogenous host-derived mediators of inflammation that are responsible for containing an infectious challenge and initiating the process of tissue repair. MODS can be conceptualized as the consequence of an overly activated or inappropriately prolonged systemic inflammatory response, therefore an understanding of the mechanisms underlying the resolution of inflammation is important to the development of clinical strategies to prevent the syndrome.
KeywordsSystemic Inflammatory Response Syndrome Tumor Necrosis Factor Receptor Multiple Organ Dysfunction Syndrome Staphylococcal Enterotoxin Neutrophil Apoptosis
- 7.Gerschenson LE, Rotello RJ (1992) Apoptosis: A different type of cell death. EASES J 6: 2450–2455Google Scholar
- 28.Woods KM, Chapes SK (1993) Three distinct cell phenotypes of induced-TNF cytotoxicity and their relationship to apoptosis. J Leuk Biol 53: 37–44Google Scholar
- 37.Watson RWG, Rotstein OD, Nathens AB, Parodo J, Marshall JC (1997) Neutrophil apoptosis is modulated by endothelial transmigration and adhesion molecule engagement. J Immunol (In Press)Google Scholar
- 40.Chitnis DC, Dickerson C, Munster AM, Winchurch RA (1996) Inhibition of apoptosis in polymorphonuclear neutrophils from burn patients. J Leuk Biol 59: 835–839Google Scholar