Introduction to the Spirochetes

  • Russell C. Johnson


The order Spirochaetales consists of helically shaped bacteria with a distinguishing anatomy and locomotion. Although these bacteria are morphologically similar, their physiology and habitats are heterogeneous. The order Spirochaetales contains obligate anaerobes, facultative anaerobes, and obligate aerobes. Substrate requirements range from fatty acids to amino acids. Habitats are extremely diverse, and range from mud to the convoluted tubules of the mammalian kidney.


Brine Shrimp Axial Filament Muramic Acid Pimelic Acid Obligate Aerobe 
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Literature Cited

  1. Anderson, D. L., Johnson, R. C. 1968. Electron microscopy of the immune disruption of leptospires: Action of complement and lysozyme. Journal of Bacteriology 95:2293–2309.PubMedGoogle Scholar
  2. Auran, N. E., Johnson, R. C., Alexander, A. D. 1975. Chemical composition and serological activity of leptospiral outer envelope. Proceedings of the National Symposium on Leptospirosis, Leptospira and other Spirochaeta. Bucharest: Ilexim.Google Scholar
  3. Auran, N. E., Johnson, R. C., Ritzi, D. M. 1972. Isolation of the outer sheath of Leptospira and its immunogenic properties in hamsters. Infection and Immunity 5:968–975.PubMedGoogle Scholar
  4. Azuma, I., Taniyama, T., Yamamura, Y., Yanagihara, Y, Hattori, S., Yasuda, S., Mifuchi, I. 1975. Chemical studies on the cell walls of Leptospira biflexa strain Urawa and Treponema pallidum strain Reiter. Japanese Journal of Microbiology 19:45–51.PubMedGoogle Scholar
  5. Azuma, I., Takeda, K., Yamamura, Y., Yanagihara, Y., Mifuchi, I. 1976. Occurrence of 3-O-methylmannose in the polysaccharide of Leptospira biflexa Urawa. Journal of Bacteriology 128:492–494.PubMedGoogle Scholar
  6. Berg, H. C. 1976. How spirochetes may swim. Journal of Theoretical Biology 56:269–273.PubMedCrossRefGoogle Scholar
  7. Bey, R. F., Auran, N. E., Johnson, R. C. 1974. Immunogenicity of whole cell and outer envelope leptospiral vaccines in hamsters. Infection and Immunity 10:1051–1056.PubMedGoogle Scholar
  8. Bharier, M. A., Eiserling, F. A., Rittenberg, S. C. 1971. Electron microscopic observations on the structure of Treponema zuelzerae and its axial filaments. Journal of Bacteriology 105:413–421.PubMedGoogle Scholar
  9. Birch-Anderson, A., Hovind-Hougen, K., Borg-Peterson, C. 1973. Electron microscopy of Leptospira. I. Leptospira strain pomona. Acta Pathologica et Microbiologica Scandinavica, Sect. B. 81:665–676.Google Scholar
  10. Blakemore, R. P., Canale-Parola, E. 1973. Morphological and ecological characteristics of Spirochaeta plicatilis. Archiv für Mikrobiologie 89:273–289.PubMedCrossRefGoogle Scholar
  11. Breznak, J. A. 1973. Biology of nonpathogenic host associated spirochetes. CRC Critical Reviews in Microbiology 2: 457–489.CrossRefGoogle Scholar
  12. Buchanan, R. E., Gibbons, N. E. (eds.). 1974. Bergey’s manual of determinative bacteriology, 8th ed., p. 1246. Baltimore: Williams & Wilkins.Google Scholar
  13. Canale-Parola, E. 1977. Physiology and evolution of spirochetes. Bacteriological Reviews 41:181–204.PubMedGoogle Scholar
  14. Cleveland, L. R., Grimstone, A. V. 1964. The fine structure of the flagellate Mixotricha paradoxa and its associated microorganisms. Proceedings of the Royal Society of London, Series B 159:668–686.CrossRefGoogle Scholar
  15. Cox, P. J., Twigg, G. I. 1974. Leptospiral motility. Nature 250:260–261.PubMedCrossRefGoogle Scholar
  16. DePamphilis, M. L., Adler, J. 1971. Fine structure and isolation of the hook-basal body complex of flagella from Escherichia coli and Bacillus subtilis. Journal of Bacteriology 105: 384–395.PubMedGoogle Scholar
  17. Fitzgerald, T. J., Johnson, R. C., Miller, J. N., Sykes, J. A. 1977. Characterization of the attachment of Treponema pallidum (Nichols strain) to cultured mammalian cells and the potential relationship of attachment to pathogenicity. Infection and Immunity 18:467–478.PubMedGoogle Scholar
  18. Ginger, C.D. 1963. Isolation and characterization of muramic acid from two spirochetes: Borrelia duttoni and Leptospira biflexa. Nature 199:159.PubMedCrossRefGoogle Scholar
  19. Hardy, P. H., Nell, E. E. 1961. Influence of osmotic pressure on the morphology of the Reiter treponeme. Journal of Bacteriology 82:967–978.PubMedGoogle Scholar
  20. Harris, D. L., Glock, R. O., Kinyon, J. M. 1976. Intestinaltrepo-nematoses, pp. 277–293. In: Johnson, R. C. (ed.), The biology of the parasitic spirochetes. New York: Academic Press.Google Scholar
  21. Hollande, A., Gharagozlou, I. 1967. Morphologie infra-structurale de Pillotina calotermititis nov. gen., nov. sp., Spirochaetale de l’intestin de Calotermes praecox. Comptes Rendus Hebdomadaires des Séances de l’Académie des Sciences, Série D 279:1939–1942.Google Scholar
  22. Holt, S. C. 1978. Anatomy and chemistry of spirochetes. Microbiological Reviews 42:114–160.PubMedGoogle Scholar
  23. Holt, S. C., Canale-Parola, E. 1968. Fine structure of Spirochaeta stenostrepta, a free living anaerobic spirochete. Journal of Bacteriology 96:822–835.PubMedGoogle Scholar
  24. Hovind-Hougen, K. 1972. Further observations on the ultrastructure of Treponema pallidum Nichols. Acta Pathologica et Microbiologica Scandinavica, Sect. B 80:297–304.Google Scholar
  25. Hovind-Hougen, K. 1974. Electron microscopy of Borrelia merionesi and Borrelia recurrentis. Acta Pathologica et Microbiologica Scandinavica, Sect. B 82:799–809.Google Scholar
  26. Hovind-Hougen, K. 1976. Determination by means of electron microscopy of morphological criteria of value for classification of some spirochetes, in particular treponemes. Acta Pathologica et Microbiologica Scandinavica, Sect. B, Suppl. 255:1–41.Google Scholar
  27. Hovind-Hougen, K., Birch-Anderson, A. 1971. Electron microscopy of endoflagella and microtubules in Treponema Reiter. Acta Pathologica et Microbiologica Scandinavica, Sect. B 79:37–50:Google Scholar
  28. Jackson, S., Black, S. H. 1971a. Ultrastructure of Treponema pallidum Nichols following lysis by physical and chemical methods. I. Envelope, wall, membrane and fibrils. Archiv für Mikrobiologie 76:308–324.PubMedCrossRefGoogle Scholar
  29. Jackson, S., Black, S. H. 1971b. Ultrastructure of Treponema pallidum Nichols following lysis by physical and chemical methods. II. Axial filaments. Archiv für Mikrobiologie 76:325–340.PubMedCrossRefGoogle Scholar
  30. Johnson, R. C. 1976. Comparative spirochete physiology and cellular composition, pp. 39–48. In: Johnson, R. C. (ed.), The biology of the parasitic spirochetes. New York: Academic Press.Google Scholar
  31. Johnson, R. C. 1977. The spirochetes. Annual Review of Microbiology 31:89–106.PubMedCrossRefGoogle Scholar
  32. Johnson, R. C., Muschel, L. H. 1966. Antileptospiral activity of serum: I. Normal and immune serum. Journal of Bacteriology 91:1403–1409.PubMedGoogle Scholar
  33. Johnson, R. C., Wachter, M. S., Ritzi, D. M. 1973. Treponemes outer cell envelope: Solubilization and reaggregation. Infection and Immunity 7:249–258.PubMedGoogle Scholar
  34. Johnson, R. C., Livermore, B. P., Walby, J. K., Jenkin, H. M. 1970a. Lipids of parasitic and saprophytic leptospires. Infection and Immunity 2:286–291.PubMedGoogle Scholar
  35. Johnson, R. C., Livermore, B. P., Jenkin, H. M., Eggebraten, L. 1970b. Lipids of Treponema pallidum Kazan 5. Infection and Immunity 2:606–609.PubMedGoogle Scholar
  36. Joseph, R. 1972. Fatty acid composition of Spirochaeta stenostrepta. Journal of Bacteriology 112:629–631.PubMedGoogle Scholar
  37. Joseph, R., Holt, S. C., Canale-Parola, E. 1973. Peptidoglycan of free-living anaerobic spirochetes. Journal of Bacteriology 115:426–435.PubMedGoogle Scholar
  38. Kaiser, G. E., Doetsch, R. N. 1975. Enhanced translational motion of Leptospira in viscous environments. Nature 255: 656–657.PubMedCrossRefGoogle Scholar
  39. Klaviter, E. C. 1975. The biology of the relapsing fever causing Borrelia. Ph.D. Thesis. University of Minnesota, Minneapolis, Minnesota.Google Scholar
  40. Kuhn, D. A. 1974. Cristispira, pp. 171–174. In: Buchanan, R. E., Gibbons, N. E. (eds.), Bergey’s manual of determinative bacteriology, 8th ed. Baltimore: Williams & Wilkins.Google Scholar
  41. Livermore, B. P., Bey, R. F., Johnson, R. C. 1978. Lipid metabolism of Borrelia hermsi. Infection and Immunity 20: 215–220.PubMedGoogle Scholar
  42. Livermore, B. P., Johnson, R. C. 1974. Lipids of the Spiro-chaetales: Comparison of the lipids of several members of the genera Spirochaeta, Treponema, and Leptospira. Journal of Bacteriology 120:1268–1273.PubMedGoogle Scholar
  43. Loesche, W. J. 1976. Periodontal disease and the treponemes, pp. 261–275. In: Johnson, R. C. (ed.), The biology of the parasitic spirochetes. New York: Academic Press.Google Scholar
  44. Margulis, L. 1975. Microtubules and evolution, p. 3. In: De Brabander, M., Borgers, M. (eds.), Microtubules and microtubule inhibitors. Proceedings of the International Symposium on Microtubules and Microtubule Inhibitors. Amsterdam, Oxford: North-Holland.Google Scholar
  45. Margulis, L., To, L., Chase, D. 1978. Microtubules in prokary-otes. Science 200:1118–1124.PubMedCrossRefGoogle Scholar
  46. Murray, R. G. E., Steed, P., Elson, H. E. 1965. The location of the mucopeptide in sections of the cell wall of Escherichia coli and other Gram-negative bacteria. Canadian Journal of Microbiology 11:547–560.PubMedCrossRefGoogle Scholar
  47. Nauman, R. K., Holt, S. C., Cox, C. D. 1969. Purification ultrastructure and composition of axial filaments from Leptospira. Journal of Bacteriology 98:264–280.PubMedGoogle Scholar
  48. Ovcinnikov, N. M., Delektorskij, V. V. 1969. Further studies of the morphology of Treponema pallidum under the electron microscope. British Journal of Venereal Diseases 44:1–34.Google Scholar
  49. Pickett, J., Kelly, R. 1974. Lipid catabolism of relapsing fever borreliae. Infection and Immunity 9:279–285.PubMedGoogle Scholar
  50. Pillot, J., Ryter, A. 1965. Structure des spirochètes. I. Étude des genres Treponema, Borrelia et Leptospira au microscope electronique. Annales de l’Institut Pasteur 108:791–804.PubMedGoogle Scholar
  51. Ritchie, A. E. 1976. Morphology of leptospires, pp. 19–37. In: Johnson, R. C. (ed.), The biology of the parasitic spirochetes. New York: Academic Press.Google Scholar
  52. Smibert, R. M. 1973. Spirochaetales, a review. CRC Critical Reviews in Microbiology 2:491–552.CrossRefGoogle Scholar
  53. Tyson, G. E. 1974a. Ultrastructure of a spirochete found in tissues of the brine shrimp, Artemia salina. Archives of Microbiology 99:281–294.PubMedCrossRefGoogle Scholar
  54. Tyson, G. E. 1974b. Distinctive renal lesion of spirochete-infected brine shrimp. Journal of Bacteriology 119:629–631.PubMedGoogle Scholar
  55. Wächter, M. S., Johnson, R. C. 1975. Treponeme outer envelope: Chemical analysis. Proceedings of the Society for Experimental Biology and Medicine 151:97–100.Google Scholar
  56. Yanagawa, R., Faine, S. 1966. Morphological and serological analysis of leptospiral structure. Nature 211:823–826.PubMedCrossRefGoogle Scholar
  57. Yanagihara, Y, Mifuchi, I. 1968. Microfibrils present in surface structure of Leptospira. Journal of Bacteriology 95: 2403–2406.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Russell C. Johnson

There are no affiliations available

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