Skip to main content
SpringerLink
Log in
Book cover

Textbook of Contact Dermatitis pp 11–27Cite as

Cellular Mechanisms in Allergic Contact Dermatitis

  • Chapter

Abstract

In the last two decades, our understanding of the basic mechanisms underlying induction, expression and regulation of allergic contact dermatitis (ACD) has rapidly increased.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boerrigter GH, Bril H, Scheper RJ (1988) Hapten-specific antibodies in allergic contact dermatitis in the guinea pig. Int Arch Allergy Appl Immunol 85: 385–391

    Article  PubMed  CAS  Google Scholar 

  2. Bergstresser PR (1989) Sensitization and elicitation of inflammation in contact dermatitis. In: Norris DA (ed) Immune mechanisms in cutaneous disease. Dekker, New York, pp 219–246

    Google Scholar 

  3. Turk JL (1975) Delayed hypersensitivity, 2nd edn. North Holland, Amsterdam

    Google Scholar 

  4. Gell PDH, Coombs RRA, Lachman R (1975) Clinical aspects of immunology, 3rd edn. Blackwell, London

    Google Scholar 

  5. Polak L (1980) Immunological aspects of contact sensitivity. An experimental study. Monogr Allergy 15: 4–60

    Google Scholar 

  6. Von Blomberg BME, Bruynzeel DP, Scheper RJ: Advances in mechanisms of allergic contact dermatitis: in vitro and in vitro. in: Dermatotoxicology, 4th ed. eds Marzulli FN, Maibach HI. Hemisphere Publishing Corporation, Washington. pp 255–362, 1991

    Google Scholar 

  7. Stingl G, Katz SI, Clement L et al. (1978) Immunological functions of Ia-bearing epidermal Langerhans cells. J Immunol 121: 2005–2013

    PubMed  CAS  Google Scholar 

  8. Czernielewski JM, Demarchez M (1987) Further evidence for the self-reproducing capacity of Langerhans cells in human skin. J Invest Dermatol 88: 17–20

    Article  PubMed  CAS  Google Scholar 

  9. Breathnach SM (1988) The Langerhans cell. Centenary review. Br J Dermatol 119: 463–469

    Article  PubMed  CAS  Google Scholar 

  10. Toews G, Bergstresser P, Streilein J et al. (1980) Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNCB. J Immunol 124: 445–453

    PubMed  CAS  Google Scholar 

  11. Halliday GM, Muller HK (1986) Induction of tolerance via skin depleted of Langerhans cells by a chemical carcinogen. Cell Immunol 99: 220–227

    Article  PubMed  CAS  Google Scholar 

  12. Marchal G, Seman M, Milon M et al. (1982) Local adoptive transfer of skin delayed type hypersensitivity initiated by a single T Lymphocyte. J Immunol 129: 954–958

    PubMed  CAS  Google Scholar 

  13. Schuler G, Steinman RM (1985) Murine epidermal Langerhans cells mature into potent immuno-stimulatory dendritic cells in vitro. J Exp Med 161: 526–546

    Article  PubMed  CAS  Google Scholar 

  14. Shimada S; Caughman SW, Sharrow SO et al. (1987) Enhanced antigen-presenting capacity of cultured Langerhans cells is associated with markedly increased expression of Ia antigen. J Immunol 139: 2551–2555

    PubMed  CAS  Google Scholar 

  15. Inaba K, Steinman RM (1986) Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering. J Exp Med 163: 247–261

    Google Scholar 

  16. Braathen LR, Thorsby E (1983) Human epidermal Langerhans cells are more potent than blood monocytes in inducing some antigen-specific T cell-responses. Br J Dermatol 108: 139–146

    Article  PubMed  CAS  Google Scholar 

  17. Res P, Kapsenberg ML, Bos JD et al. (1987) The crucial role of human dendritic antigen-presenting cell subsets in nickel-specific T cell proliferation. J Invest Dermatol 88: 550–554

    Article  PubMed  CAS  Google Scholar 

  18. Cresswell P (1987) Antigen recognition by T lymphocytes. Immunol Today 8: 67–69

    Article  Google Scholar 

  19. Claverie JM, Prochnicka-Chalufour A, Bougueleret L (1989) Implications of a Fab-like structure for the T cell receptor. Immunol Today 10: 10–14

    Article  PubMed  CAS  Google Scholar 

  20. Shimada S, Katz SI (1985) TNP-specific Lyt-2+ cytolytic T cell clones preferentially respond to TNP-conjugated epidermal cells. J Immunol 135: 1558–1563

    PubMed  CAS  Google Scholar 

  21. Sinigaglia F, Scheidegger D, Garotta G et al. (1985) Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis. J Immunol 135: 3929–3932

    PubMed  CAS  Google Scholar 

  22. Sanders ME, Makgoba MW, Shaw S (1988) Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets. Immunol Today 9: 195–198

    Article  PubMed  CAS  Google Scholar 

  23. Dohlsten M, Hedlund G, Sjogren H et al. (1988) Two subsets of human CD4+ T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-gamma can be defined by the Leu 18 and UCHL1 monoclonal antibodies. Eur J Immunol 18: 1173–1178

    Article  PubMed  CAS  Google Scholar 

  24. Bos JD, Zonneveld I, Das PK et al. (1987) The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88: 569–573

    Article  PubMed  CAS  Google Scholar 

  25. von Blomberg BME, van der Burg CKH, Pos O et al. (1987) In vitro studies in nickel allergy: diagnostic value of a dual parameter analyis. J Invest Dermatol 88: 362–368

    Article  Google Scholar 

  26. Hirschberg H, Braathen LR, Thorsby E (1982) Antigen presentation by vascular endothelial cells and epidermal Langerhans cells: the role of HLA-DR Immunol Rev 65: 57–77

    Google Scholar 

  27. Breitmeyer JB (1987) Lymphocyte activation. How T cells communicate. Nature 329: 760–761

    Article  PubMed  CAS  Google Scholar 

  28. Bierer BE, Burakoff SJ (1988) T cell adhesion molecules. FASEB J 2: 2584–2590

    CAS  Google Scholar 

  29. Issekutz TB, Stoltz JM, von der Meide P (1988) Lymphocyte recruitment in delayed hypersensitivity; the role of interferon-gamma. J Immunol 140: 2989–2993

    PubMed  CAS  Google Scholar 

  30. Messadi DV, Pober JS, Fiers W et al. (1987) Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture. J Immunol 139: 1557–1562

    PubMed  CAS  Google Scholar 

  31. Haskard DO, Cavender D, Fleck RM et al. (1987) Human dermal microvascular endothelial cells behave like umbilical vein endothelial cells in T cell adhesion studies. J Invest Dermatol 88: 340–344

    Article  PubMed  CAS  Google Scholar 

  32. Dustin ML, Rothlein R, Bhan AK et al. (1986) Induction by IL-1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molucule (ICAM-1). J Immunol 137: 245–254

    PubMed  CAS  Google Scholar 

  33. Hamann A, Jablonski-Westrich D, Scholz KW et al. (1988) Regulation of lymphocyte homing. I. Alterations in homing receptor expression and organ-specific high endothelial venule binding of lymphocytes upon activation. J Immunol 140: 737–741

    PubMed  CAS  Google Scholar 

  34. Scheper RJ, Von Blomberg BME (1989) Allergic contact dermatitis: T cell receptors and migration. In: Frosch PJ, Dooms-Goossens A, Lachapelle JM, Rycroft RJG, Scheper RJ (eds) Current topics in contact dermatitis. Springer, Berlin Heidelberg New York, pp 12–17

    Chapter  Google Scholar 

  35. Pals ST, Horst E, Scheper RJ et al. (1989) Mechanisms of human lymphocyte migration and their role in the pathogenesis of disease. Immunol Rev 108: 111–133

    Article  PubMed  CAS  Google Scholar 

  36. Duijvesteijn A, Hamann A (1989) Mechanisms and regulation of lymphocyte migration. Immunol Today 10: 23–28

    Article  Google Scholar 

  37. Silvennoinen-Kassinen S, Jakkula H, Karvonen J (1986) Helper T cells carry the specificity of nickel sensitivity reaction in vitro in humans. J Invest Dermatol 86: 18–20

    Article  PubMed  CAS  Google Scholar 

  38. Scheper RJ, von Blomberg BME, Velzen D et al. (1976) Effects of contact sensitization and delayed hyper-sensitivity reactions on immune responses to non-related antigens. Modulation of immune responses. Int Arch Allergy Appl Immunol 50: 243–255

    Article  PubMed  CAS  Google Scholar 

  39. Camarasa JG, Serra-Baldrich E, Lluch M et al. (1989) Recent unexplained patch test reactions to palladium. Contact Dermatitis 20: 388–399

    Article  PubMed  CAS  Google Scholar 

  40. Skog E (1966) Spontaneous flare-up reactions induced by different amounts of 1,3-dinitro-4-chlorobenzene. Acta Derm Venereol (Stockh) 46: 386–395

    CAS  Google Scholar 

  41. Scheper RJ, von Blomberg BNE, Boerrigter GH et al. (1983) Induction of local memory in the skin. Role of local T cell retention. Clin Exp Immunol 51: 141–151

    PubMed  CAS  Google Scholar 

  42. Yamashita N, Natsuaki M, Sagami S (1989) Flare-up reaction on murine contact hypersensitivity. I. Description of an experimental model: rechallenge system. Immunology 67: 365–369

    PubMed  CAS  Google Scholar 

  43. Scheper RJ, van Dinther-Janssen ACHM, Polak L (1985) Specific accumulation of hapten-reactive T cells in contact sensitivity reaction sites. J Immunol 134: 1333–1336

    PubMed  CAS  Google Scholar 

  44. Miller SD, Sy M-S, Claman HN (1977) The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state. Eur J Immunol 7: 165–170

    Google Scholar 

  45. Mowat A (1987) The regulation of immune responses to dietary protein antigens. Immunol Today 8: 93–98

    Article  CAS  Google Scholar 

  46. van Hoogstraten IMW, Andersen JE, von Blomberg BME et al. (1989) Preliminary results of a multicenter study on the incidence of nickel allergy in relationship to previous oral and cutaneous contacts. In: Frosch PJ, Dooms-Goosens A, Lachapelle JM, Rycroft RJG, Scheper RJ (eds) Current topics in contact dermatitis. Springer, Berlin Heidelberg New York pp 178–184

    Google Scholar 

  47. Semma M, Sagami S (1981) Induction of suppressor T cells to DNFB contact sensitivity by application of sensitizer through Langerhans cell-deficient skin. Arch Dermatol Res 271: 361–364

    Article  PubMed  CAS  Google Scholar 

  48. Elmets CA, Bergstresser PR, Tigelaar RE et al. (1983) Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to ultraviolet radiation. J Exp Med 158: 781–794

    Article  PubMed  CAS  Google Scholar 

  49. Zembala M, Asherson GL (1973) Depression of T cell phenomenon of contact sensitivity by T cells from unresponsive mice. Nature 244: 227–228

    Article  PubMed  CAS  Google Scholar 

  50. Epstein WL (1987) The poison ivy picker of Pennypack Park: the continuing saga of poison ivy. J Invest Dermatol 88: 7–9

    Article  Google Scholar 

  51. Chase MW (1946) Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 61: 257–259

    Article  PubMed  CAS  Google Scholar 

  52. Polak L, Turk JL (1968) Studies on the effect of systemic administration of sensitizers in guinea pigs with contact sensitivity to inorganic metal compounds. I. The induction of immunological unresponsiveness in already sensitized animals. Clin Exp Immunol 3: 245–251

    Google Scholar 

  53. Wendel GD, Stark BJ, Jamison RB et al. (1985) Penicillin allergy and desensitization in serious infections during pregnancy. N Engl J Med 312: 1229–1232

    Article  PubMed  Google Scholar 

  54. Polak L, Rinck C (1978) Mechanism of desensitization in DNCB-contact sensitive guinea pigs. J Invest Dermatol 70: 98–104

    Article  PubMed  CAS  Google Scholar 

  55. Gaspari AA, Jenkins MK, Katz SI (1988) Class II MCH-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific TH1 clones. J Immunol 141: 2216–2220

    PubMed  CAS  Google Scholar 

  56. Boerrigter GH, Scheper RJ (1987) Local and systemic desensitization induced by repeated epicutaneous hapten application. J Invest Dermatol 88: 3–7

    Article  PubMed  CAS  Google Scholar 

  57. Menne T, Brandrup F, Thestrup-Pedersen K et al. (1987) Patch test reactivity to nickel alloys. Contact Dermatitis 16: 255–259

    Article  PubMed  CAS  Google Scholar 

  58. Magnusson B, Kligman AM (1977) Usefulness of guinea pig tests for detection of contact sensitizers. In: Marzulli FN, Maibach HI (eds) Dermatotoxicology and pharmacology. Wiley, London, pp 551–560

    Google Scholar 

  59. Klecak G (1983) Identification of contact allergens: predictive tests in animals. In: Marzuli FN, Maibach HI (eds) Dermatotoxicology. McGraw-Hill, New York, pp 193–237

    Google Scholar 

  60. Maguire HC (1985) Estimation of the allergenicity of prospective human contact sensitizers in the guinea pig. In: Maibach HI, Lowe N (eds) Models in dermatology, vol 2. Karger, Basel, pp 234–239

    Google Scholar 

  61. Maurer T (1983) Contact and photocontact allergens: a manual of predictive test methods. Dekker, New York

    Google Scholar 

  62. Maibach H (1985) Clonidine: irritant and allergic contact dermatitis assays. Contact Dermatitis 12: 192–195

    Article  PubMed  CAS  Google Scholar 

  63. Kimber I, Mitchell JA, Griffin AC (1986) Development of a murine local lymph node assay for the determination of sensitizing potential. Food Chem Toxicol 24: 585–586

    Article  CAS  Google Scholar 

  64. Kimber I (1988) Immunotoxicology and allergy: old problems and new approaches. Toxic in Vitro 2: 309–311

    Article  CAS  Google Scholar 

  65. Knapp W, Rieber P, Dorken B et al. (1989) Towards a better definition of human leucocyte surface molecules. Immunol Today 10: 253–258

    Article  PubMed  CAS  Google Scholar 

  66. Knop J, Stremmer R, Neumann C, De Maeyer D, Macher E (1982) Interferon inhibits the suppressor T cell response of delayed-type hypersensitivity. Nature 296: 775–776

    Article  Google Scholar 

Download references

Authors
  1. Rik J. Scheper
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Mary E. von Blomberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Contact Dermatitis Clinic, St. John’s Dermatology Centre, St. Thomas’s Hospital, Lambeth Palace RD, SE1 7 EH, London, UK

    Richard J. G. Rycroft

  2. Department of Dermatology, Gentofte Hospital University of Copenhagen, Niels Andersens Vej 65, 2900, Hellerup, Denmark

    Torkil Menné

  3. Hautklinik der Städtischen Kliniken Dortmund, Abteilung Dermatologie, Universität Witten/Herdecke, Beurhausstraße 40, 4600, Dortmund, Germany

    Peter J. Frosch

  4. Laboratoire de Dermatochimie, Université Louis Pasteur, Clinique Dermatologique, 1 Place de l’Hôpital, 67091, Strasbourg Cedex, France

    Claude Benezra

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Scheper, R.J., von Blomberg, B.M.E. (1992). Cellular Mechanisms in Allergic Contact Dermatitis. In: Rycroft, R.J.G., Menné, T., Frosch, P.J., Benezra, C. (eds) Textbook of Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13119-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-13119-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-13121-3

  • Online ISBN: 978-3-662-13119-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation