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Textbook of Contact Dermatitis pp 323–338Cite as

Noninvasive Techniques for Quantification of Contact Dermatitis

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Abstract

History and clinical examination are the main tools of clinical dermatologists. Inspection of the skin is rapid, and the lateral extension and severity of a dermatitis is easily assessed. The disadvantage is that this method is essentially subjective. As a research tool it is open to bias and thus difficult to use.

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References

  1. Rothman S (ed) (1954) Physiology and biochemistry of the skin. University of Chicago Press, Chicago

    Google Scholar 

  2. Goldsmith LA (ed) (1983) Biochemistry and physiology of the skin. Oxford University Press, New York

    Google Scholar 

  3. Leveque JL (ed) (1989) Cutaneous investigation in health and disease. Noninvasive methods and instrumentation. Dekker, New York

    Google Scholar 

  4. Rietschel RL, Spencer TS (eds) (1990) Methods for cutaneous investigation. Dekker, New York (Cosmetic science and technology series)

    Google Scholar 

  5. Marks R, Payne PA (eds) (1981) Bioengineering and the skin. MTP Press, Lancaster

    Google Scholar 

  6. Shepherd AP,Oberg PA (eds) (1990) Laser-Doppler blood flowmetry. Kluwer, Boston

    Google Scholar 

  7. Stüttgen G, Flesch U (1985) Dermatological thermography. In: Engel JM et al. (eds) Thermologic methods. VCH Weinheim

    Google Scholar 

  8. Berardesca E, Maibach HI (1988) Bioengineering and the patch test. Contact Dermatitis 18: 3–9

    Article  PubMed  CAS  Google Scholar 

  9. Diffey BL, Oliver RJ, Farr PM (1984) A portable instrument for quantifying erythema induced by ultraviolet radiation. Br J Dermatol 111: 663–672

    Article  PubMed  CAS  Google Scholar 

  10. Robertson AR (1977) The CIE 1976 color difference formulas. Color Res Appl 2: 7–11

    Google Scholar 

  11. Serup J, Agner T (1990) Colorimetric quantification of erythema — comparison of two colorimeters (Lange Micro Color and Minolta Chroma Meter CR-200) with a clinical scoring scheme and laser-Doppler flowmetry. Clin Exp Dermatol 15: 267–272

    Article  PubMed  CAS  Google Scholar 

  12. Slue WE (1989) Photographic cures for dermatologie disorders. Arch Dermatol 125: 960–962

    Article  PubMed  Google Scholar 

  13. Grove GL, Grove MJ (1989) Objective methods for assessing skin surface topography noninvasively. In: Leveque J-L (ed) Cutaneous investigation in health and disease Dekker, New York

    Google Scholar 

  14. Serup J, Winther A, Blichmann C (1989) A simple method for the study of scale pattern and effects of a moisturizer — qualitative and quantitative evaluation by D-Squame tape compared with parameters of epidermal hydration. Clin Exp Dermatol 14: 277–282

    Article  PubMed  CAS  Google Scholar 

  15. Leveque J-L, deRigal J (1983) Impedance methods for studying skin moisturisation. J Soc Cosmet Chem 34: 419–426

    CAS  Google Scholar 

  16. Tagami H (1989) Impedance measurement for evaluation of the hydration state of the skin surface. In: Leveque J-L (ed) Cutaneous investigation in health and disease. Dekker, New York pp 79–111

    Google Scholar 

  17. Blichmann C, Serup J (1988) Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss. Acta Derm Venereol (Stockh) 68: 284–290.

    Google Scholar 

  18. Agner T, Serup J (1988) Comparison of two electrical methods for measurement of skin hydration. An experimental study on irritant patch test reactions. Bioeng Skin 4: 263–269

    Google Scholar 

  19. Stender IM, Blichmann C, Serup J (1990) Effects of oil and water baths on the hydration state of the epidermis. Clin Exp Dermatol 15: 206–209

    Article  PubMed  CAS  Google Scholar 

  20. Nilsson GE (1977) Measurement of water exchange through skin. Med Biol Eng Comput 15: 209–218

    Article  PubMed  CAS  Google Scholar 

  21. Spencer TS (1990) Transepidermal water loss: methods and applications. In: Rietschel RL, Spencer TS (eds) Methods for cutaneous investigation. Dekker, New York, pp 191–217

    Google Scholar 

  22. Pinnagoda J, Tupker RA, Agner T, Serup J (1990) Guidelines for transepidermal water loss (TEWL) measurement. A report from the standardization group of the European Society of Contact Dermatitis. Contact Dermatitis 22: 164–178

    Google Scholar 

  23. Agner T, Serup J (1989) Seasonal variation of skin resistance to irritants. Br J Dermatol 121: 323–328

    Article  PubMed  CAS  Google Scholar 

  24. Agner T, Serup J (1988) Contact thermography for assessment of skin damage due to experimental irritants. Acta Derm Venereol (Stockh) 68: 192–195

    CAS  Google Scholar 

  25. Baillie AJ, Biagioni PA, Forsyth A, Garioch JJ, McPherson D (1990) Thermographic assessment of patch-test responses. Br J Dermatol 122: 351–360

    Article  PubMed  CAS  Google Scholar 

  26. Serup J, Staberg B (1987) Ultrasound for assessment of allergic and irritant patch test reactions. Contact Dermatitis 17: 80–84

    Article  PubMed  CAS  Google Scholar 

  27. Serup J (1991) Ten years of experience with high-frequency ultrasound examination of the skin: development and refinement of technique and equipments. In: Altmeyer P et al. (eds) Ultrasound examination of skin. Karger, Basel (in press)

    Google Scholar 

  28. Peters K, Serup J (1987) Papulo-vesicular count for the rating of allergic patch test reactions. A simple technique based on polysulfide rubber replica. Acta Derm Venereol (Stockh) 67: 491–495

    Google Scholar 

  29. Blichmann C, Serup J (1987) Hydration studies on scaly hand eczema. Contact Dermatitis 16: 155–159

    Article  PubMed  CAS  Google Scholar 

  30. Serup J, Staberg B (1987) Differentiation of allergic and irritant reactions by transepidermal water loss. Contact Dermatitis 16: 129–132

    Article  PubMed  CAS  Google Scholar 

  31. Serup J (1987) Contact thermography — towards the Sherlock Holmes magnifying glass for solving allergic and irritant patch test reactions? Contact Dermatitis 17: 61–63

    Article  PubMed  CAS  Google Scholar 

  32. Staberg B, Serup J (1984) Patch test responses evaluated by cutaneous blood flow measurements. Arch Dermatol 120: 741–743

    Article  PubMed  CAS  Google Scholar 

  33. Staberg B, Serup J (1988) Allergic and irritant skin reactions evaluated by laser Doppler flowmetry. Contact Dermatitis 18: 40–45

    Article  PubMed  CAS  Google Scholar 

  34. Serup J, Staberg B, Klemp P (1984) Quantification of cutaneous oedema in patch test reactions by measurement of skin thickness with high-frequency pulsed ultrasound. Contact Dermatitis 10: 88–93

    Article  PubMed  CAS  Google Scholar 

  35. Willis CM, Stephens CJM, Wilkinson JD (1989) Epidermal damage induced by irritants in man: a light and electron microscopy study. J Invest Dermatol 93: 695–699

    Article  PubMed  CAS  Google Scholar 

  36. Björnberg A (1968) Skin reactions to primary irritants in patients with hand eczema. An investigation with matched controls. Isacson, Göteborg

    Google Scholar 

  37. Frosch P (1985) Hautirritation and empfindliche Haut. Grosse, Berlin

    Google Scholar 

  38. van der Valk PGM (1983) Water vapour loss measurements on human skin. Thesis, State University Hospital, Gröningen

    Google Scholar 

  39. Pinnagoda J (1990) Transepidermal water loss. Its role in the assessment of susceptibility to the development of irritant contact dermatitis. Thesis, State University Hospital, Gröningen

    Google Scholar 

  40. Tupker Ra (1990) The influence of dertergents on the human skin. A study on factors determining the individual susceptibility assessed by transepidermal water loss. Thesis, State University Hospital, Gröningen

    Google Scholar 

  41. de Boer EM (1989) Occupational dermatitis by metalworking fluids. An epidemiological study and an investigation on skin irritation using laser Doppler flowmetry. Thesis, Vrije University, Amsterdam

    Google Scholar 

  42. Agner T (1991) Noninvasive measuring methods for the investigation of irritant contact dermatitis. Thesis, University of Copenhagen

    Google Scholar 

  43. Agner T,Serup J (1990) Sodium lauryl sulphate for irritant patch testing. A dose-response study using bioengineering methods for determination of skin irritation. J Invest Dermatol 95: 543–547

    Article  Google Scholar 

  44. Agner T, Serup J (1987) Skin reactions to irritants assessed by polysulfide rubber replica. Contact Dermatitis 17: 205–211

    Article  PubMed  CAS  Google Scholar 

  45. Agner T,Serup J (1990) Individual and instrumental variations in irritant patch-test reactions — clinical evaluation and quantification by bioengineering methods. Clin Exp Dermatol 15: 29–33

    Article  Google Scholar 

  46. Bircher AJ, Guy RH, Maibach HI (1990) Laser-Doppler blood flowmetry. Skin pharmacology and dermatology. In: Shepherd AP, ()berg PA (eds) Laser-Doppler blood flowmetry. Kluwer, Boston, pp 141–174

    Google Scholar 

  47. Frosch PJ, Kligman AM (1982) Recognition of chemically vulnerable and delicate skin. In: Frost PH, Horwitz SN (eds) Principles of cosmetics for the dermatologist. Mosby, St Luis, pp 287–296

    Google Scholar 

  48. Murahata RI, Crowe DM, Roheim JR (1986) The use of transepidermal water loss to measure and predict the irritation response to surfactants. Int J Cosmet Sci 8: 225–231

    Article  PubMed  CAS  Google Scholar 

  49. Frosch P, Wissing C (1982) Cutaneous sensitivity to ultraviolet light and chemical irritants. Arch Dermatol Res 272: 269–278

    Article  PubMed  CAS  Google Scholar 

  50. Agner T, Damm P, Skouby SO (1991) Menstrual cycle and skin rectivity. J Am Acad Dermatol 24: 566–570

    Article  PubMed  CAS  Google Scholar 

  51. Werner Y, Lindberg M (1985) Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Arch Dermatol Res 65: 102–105

    CAS  Google Scholar 

  52. Agner T (1991) Skin susceptibility in uninvolved skin of hand eczema patients and healthy controls. Br J Dermatol 125: 140–146

    Article  PubMed  CAS  Google Scholar 

  53. Agner T (1990) Susceptibility to sodium lauryl sulphate in patients with atopic dermatitis and controls. Acta Derm Venerol (Stockh) 71: 296–300

    Google Scholar 

  54. Serup J, Staberg B (1985) Quantification of weal reactions with laser Doppler flowmetry. Comparative blood flow measurements of the oedematous centre and the perilesional flare of skin-prick histamine weals. Allergy 40: 233–237

    Google Scholar 

  55. van Neste D (1991) Skin response to histamine: reproducibility study of the dry skin prick test method and of the evaluation of microvascular changes with laser Doppler flowmetry. Acta Derm Venereol (Stockh) 71: 25–28

    Google Scholar 

  56. Serup J (1984) Diameter, thickness, area, and volume of skin-prick histamine weals. Allergy 39: 359–364

    Article  PubMed  CAS  Google Scholar 

  57. Agner T, Serup J (1989) Quantification of the DMSO-response, a test for assessment of sensitive skin. Clin Exp Dermatol 14: 214–217

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Jørgen Serup
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Editor information

Editors and Affiliations

  1. Contact Dermatitis Clinic, St. John’s Dermatology Centre, St. Thomas’s Hospital, Lambeth Palace RD, SE1 7 EH, London, UK

    Richard J. G. Rycroft

  2. Department of Dermatology, Gentofte Hospital University of Copenhagen, Niels Andersens Vej 65, 2900, Hellerup, Denmark

    Torkil Menné

  3. Hautklinik der Städtischen Kliniken Dortmund, Abteilung Dermatologie, Universität Witten/Herdecke, Beurhausstraße 40, 4600, Dortmund, Germany

    Peter J. Frosch

  4. Laboratoire de Dermatochimie, Université Louis Pasteur, Clinique Dermatologique, 1 Place de l’Hôpital, 67091, Strasbourg Cedex, France

    Claude Benezra

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© 1992 Springer-Verlag Berlin Heidelberg

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Serup, J. (1992). Noninvasive Techniques for Quantification of Contact Dermatitis. In: Rycroft, R.J.G., Menné, T., Frosch, P.J., Benezra, C. (eds) Textbook of Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13119-0_19

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  • DOI: https://doi.org/10.1007/978-3-662-13119-0_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-13121-3

  • Online ISBN: 978-3-662-13119-0

  • eBook Packages: Springer Book Archive

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