Abstract
Pain is a subjective experience reflecting actual, assumed or potential tissue damage, variable in intensity and, in general, localizable in space and in time. It is comprised of not only a sensory/perceptive but also of an emotional/affective and cognitive/conscious component. Though of limited utility, such a characterization has the virtue of drawing attention to the complexity of pain and to the fact that it is a phenomenon which can be monitored from its inception in sensory nerve endings, via the spinal cord and brainstem, to the highest levels of the CNS, the limbic system and cortex. At each level of this hierarchy of processing and integration, mechanisms for its modulation are operative and each level offers the possibility of therapeutic intervention in pain control.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Basbaum A, Fields HL (1984) Endogenous pain control systems. Ann Rev Neurosci 7: 309–338
Brown AG (1981) Organization in the spinal cord. Springer Verlag, Berlin
Dubner R, Bennett GJ (1983) Spinal and trigeminal mechanism of nociception. Ann Rev Neurosci 6: 381–418
Fields HL, Dubner R, Cervero F (1985) (eds) Advances in Pain Research and Therapy, Vol 9, Raven Press, New York
Fitzgerald M (1986) Monoamines and descending control of nociception. Trends Neurosci 7: 5–7
Goodman GA, Goodman LS, Rall TW, Murad F (1985) The pharmacological basis of experimental therapeutics. MacMillan, New York
Iggo A, Streedman WM, Fleetwood-Walker B (1986) Spinal processing: anatomy and physiology of spinal nociception, Phil Trans R Soc Lond B 308: 235–252
Inoki R and Kudo T (1986) Enkephalins and bradykinin in dental pulp, Trends Pharm 7: 275–279
Kelly DJ (1986) (ed) Stress-induced analgesia, Ann NY Acad Science, vol 467
Mayer DJ (1980) Centrifugal central of pain. In: Ng, LL, Bonica J (eds) Pain, Discomfort and humanitarian care. Elsevier Press, Amsterdam, pp 83–105
Millan MJ (1982) Endorphins and nociception: an overview, Meth Find Exp Clin Pharmacol 4: 445–462
Millan MJ (1986) Multiple opioid systems and pain, Pain 27: 303–349
Millan MJ (1981) Stress and endogenous opioid peptides; a review. Mod Probi Pharmacopsychiat 17:49–67
Millan MJ, Duka Th (1981) Anxiolytic properties of opiates and endogenous opioid peptides and their relationship to the action of benzodiazepines, Mod Probi Pharmacopsychiat 17: 123–141
Pert A (1980) Psychopharmacology of analgesia and pain. In: Ng LL and Bonica J (eds) Pain, Discomfort and Humanitarian Care, Elsevier Press, Amsterdam, pp 139–191
Ruda MA, Bennett GJ, Dubner RJ (1986) Neurochemistry and neural circuitry in the dorsal horn, Prog Brain Res 66: 219–268
Siggins GR, Gruol DL (1986) Mechanisms of transmitter action. In: Mountcastle VB, Bloom FE and Geiger SR (eds) Handbook of Physiology — The Nervous System, vol. IV, Williams and Wilkins, Baltimore, pp 44–114
Tohyama M, Shiotani M (1986) Neuropeptides in spinal cord. Prog Brain Res 66: 177–218
Wall P (1980) The substantia gelatinosa; A gate control mechanism set across a sensory pathway, Trends Neurosci 3: 221–224
Watkins LR, Mayer DJ (1982) Organization of endogenous opiate and non-opiate pain control systems, Science 216: 1185–1192
Wilder A (1980) Opioid Dependence, Plenum Press, New York
Yaksh TL, Hammond DH (1982) Peripheral and central substrates involved in the rostral transmission of nociception information. Pain 13: 1–85
Zadina JE, Banks WA, Kastin AJ (1986) Central nervous system effects of peptides, 1980–1985, Peptides 7: 497–537
Zieglgänsberger W (1986) Central control of nociception. In: Mountcastle VB, Bloom FE and Geiger SR (eds) Handbook of Physiology — The Nervous System, Vol IV, Williams and Wilkins, Baltimore, pp 581–645
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Millan, M.J. (1987). Central mechanisms of pain control: a survey. In: v. Arnim, T., Maseri, A. (eds) Silent Ischemia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-12997-5_1
Download citation
DOI: https://doi.org/10.1007/978-3-662-12997-5_1
Publisher Name: Steinkopff, Heidelberg
Print ISBN: 978-3-662-12999-9
Online ISBN: 978-3-662-12997-5
eBook Packages: Springer Book Archive