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Abstract

In the Preface we discussed two questions which encompass most of the research on the cytoskeleton and signaling:

  1. 1)

    How are the structure and function of the cytoskeleton affected by external signals which impinge on the cell?

  2. 2)

    How does the cytoskeleton influence the cellular signaling processes which determine cell behaviors?

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References

  1. Carraway KL, Carraway CAC. Signaling, mitogenesis and the cytoskeleton: where the action is. Bioessays 1995; 17: 71–175.

    Article  Google Scholar 

  2. Fincham VJ, Unlu M, Brunton VG, Pitts JD, Wyke JA, Frame MC. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G-proteins. J Cell Biol 1996; 135: 1551–1564.

    Article  PubMed  CAS  Google Scholar 

  3. Edwards DR. Cell signalling and the control of gene transcription. Trends Pharm Sci 1994; 15: 239–244.

    Article  PubMed  CAS  Google Scholar 

  4. Carpenter CL, Cantley LC. Phosphoinositide 3-kinase and the regulation of cell growth. Biochim Biophys Acta 1996; 1288: M11 - M16.

    PubMed  Google Scholar 

  5. Carraway KL III, Cantley LC. A neu acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerization in growth signaling. Cell 1994; 78: 5–8.

    Article  PubMed  CAS  Google Scholar 

  6. Cantley LG. Growth factors and the kidney: regulation of epithelial cell movement and morphogenesis. Am J Physiol 1996; 271: F1103–13.

    PubMed  CAS  Google Scholar 

  7. Lim L, Hall C, Monfries C. Regulation of actin cytoskeleton by Rho-family GTPases and their associated proteins. Sem Cell Devel Biol 1996; 7: 699–706.

    Article  CAS  Google Scholar 

  8. Yarden Y, Ullrich A. Growth factor receptor tyrosine kinases. Annu Rev Biochem 1988; 57: 443–478.

    Article  PubMed  CAS  Google Scholar 

  9. Hausdorff WP, Caron M, Lefkowitz RJ. Turning off the signal: desensitization of (3-adrenergic receptor function. FASEB J 1990; 4: 2881–2889.

    PubMed  CAS  Google Scholar 

  10. Brown MT, Cooper JA. Regulation, substrates and functions of src. Biochim Biophys Acta 1996; 1287: 121–149.

    PubMed  Google Scholar 

  11. Carraway CAC, Carraway KL. Interactions of membrane receptors and cell signalling systems with the cytoskeleton. In: Hesketh HE, Pryme IF, eds. Treatise on the Cytoskeleton, vol. 2, Role in Cell Physiology 1996; 207–238, Greenwich, CT: JAI Press Inc.

    Google Scholar 

  12. Loeb JA, Fischbach GD. ARIA can be released from extracellular matrix through cleavage of a heparin-binding domain. 1995; J Cell Biol 130: 127–135.

    Article  PubMed  CAS  Google Scholar 

  13. Carraway KL, Carraway CAC, Carraway KL III. Roles of ErbB-3 and ErbB-4 in the physiology and pathology of the mammary gland. J Mammary Gland Biol Neoplasia 1997; 2: 187–198.

    Article  PubMed  CAS  Google Scholar 

  14. Lemmon MA, Falasca M, Ferguson KM, Schlessinger J. Regulatory recruitment of signalling molecules to the cell membrane by pleckstrin-homology domains. Trends Cell Biol 1997; 7: 237–242.

    Article  CAS  Google Scholar 

  15. Wu D, Wallen HD, Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 1997; 275: 1126–1129.

    Article  PubMed  CAS  Google Scholar 

  16. Pratt WB, Sanchez ER, Bresnick EH, Meshinchi S, Scherrer LC, Dalman FC, Welsh MJ. Interaction of the glucocorticoid receptor with the Mr 90,00o heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation. Cancer Res 1989; 49: 2222s - 2229s.

    PubMed  CAS  Google Scholar 

  17. Frankel S, Mooseker MS. The actin-related proteins. Curr Opin Cell Biol 1996; 8:30-37.

    Google Scholar 

  18. Weeds A, Maciver S. F-actin capping proteins. Curr Opin Cell Biol 1993; 5: 63–69.

    Article  PubMed  CAS  Google Scholar 

  19. Tsang TC. New model for 7o kDa heat-shock protein’s potential mechanisms of function. FEBS Lett 1993; 323: 1–3.

    Article  PubMed  CAS  Google Scholar 

  20. Landry J, Huot J. Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27. Biochem Cell Biol 1995; 73: 703–707.

    Article  PubMed  CAS  Google Scholar 

  21. Carraway CAC, Carvajal ME, Carraway KL. Association of the Ras/MAP kinase signal transduction pathway with microfilaments. Evidence for a p185neu-contaiaing cell surface signal transduction particle. Submitted.

    Google Scholar 

  22. Stokoe D, Macdonald SG, Cadwallader K, Symons M, Hancock JF. Activation of Raf as a result of recruitment to the plasma membrane. Science 1994; 264: 1463–1467.

    Article  PubMed  CAS  Google Scholar 

  23. Chant J. Cell polarity in yeast. Trends in Genetics 1994; 10: 328–333.

    Article  PubMed  CAS  Google Scholar 

  24. Crews CM, Alessandrini A, Erikson RL. Erks: their fifteen minutes has arrived. Cell Growth Differ 1992; 3: 135–42.

    PubMed  CAS  Google Scholar 

  25. Condeelis J. Elongation factor 1a, translation and the cytoskeleton. Trends Biochem Sci 1995; 20: 169–170.

    Article  PubMed  CAS  Google Scholar 

  26. Durso NA, Cyr RJ. A calmodulin-sensitive interaction between microtubules and a higher plant homolog of elongation factor-1. Plant Cell 1994; 6893–905.

    Google Scholar 

  27. Shiina N, Gotoh Y, Kubomura N, Iwamatsu A, Nishida E. Microtubule severing by elongation factor. Science 1994; 266: 282–285.

    Article  PubMed  CAS  Google Scholar 

  28. Dharmawardhane S, Demma M, Yang F, Condeelis J. Compartmentalization and actin binding properties of ABP-5o: the elongation factor-1 of Dictyostelium. Cell Motil Cytoskeleton 1991; 20: 279–288.

    Article  PubMed  CAS  Google Scholar 

  29. Kurasawa Y, Hanyu K, Watanabe Y, Numata O. F-actin bundling activity of Tetrahymena elongation factors is regulated by Ca2+/calmodulin. J Biochem (Tokyo). 1996; 119: 791–798.

    Article  CAS  Google Scholar 

  30. Yang F, Demma M, Warren V, Dharmawardhane S, Condeelis J. Identification of an actin-binding protein from Dictyostelium as elongation factor la. Nature 1990; 347: 494–496.

    Article  PubMed  CAS  Google Scholar 

  31. Owen CH, DeRosier DJ, Condeelis J. Actin crosslinking protein EF-la of Dictyostelium discoideum has a unique bonding rule that allows square-packed bundles. J Struct Biol 1992; 109: 248–254.

    Article  PubMed  CAS  Google Scholar 

  32. Bassell G, Singer RH. mRNA and cytoskeletal filaments. Curr Opin Cell Biol 1997; 9: 109–115.

    Article  PubMed  CAS  Google Scholar 

  33. Hesketh JE. Sorting of messenger RNAs in the cytoplasm: mRNA localization and the cytoskeleton. Exp Cell Res 1996; 225: 219–236.

    Article  PubMed  CAS  Google Scholar 

  34. Singer RH. The cytoskeleton and mRNA localization. Curr Opin Cell Biol 1992; 4: 15–19.

    Article  PubMed  CAS  Google Scholar 

  35. Negrutskii BS, Deutscher MP. Channeling of aminoacyl-tRNA for protein synthesis in vivo. Proc Natl Acad Sci USA 1991; 88: 4991–4995.

    Article  PubMed  CAS  Google Scholar 

  36. Srere, P. Complexes of sequential metabolic enzymes. Annu Rev Biochem 1987; 56: 89–124.

    Article  PubMed  CAS  Google Scholar 

  37. Pawson T, Gish GD. SH2 and SH3 domains: from structure to function. Cell 1992; 71: 359–362.

    Article  PubMed  CAS  Google Scholar 

  38. Mayer BJ, Baltimore D. Signalling through SH2 and SH3 domains. Trends Cell Biol 1993; 3: 8–13.

    Article  PubMed  CAS  Google Scholar 

  39. Varticovski L, Harrison-Findik D, Keeler ML, Susa M. Role of PI 3-kinase in mitogenesis. Biochim Biophys Acta 1994; 1226: 1–11.

    Article  PubMed  CAS  Google Scholar 

  40. Kapeller R, Cantley LC. Phosphatidylinositol 3-kinase. BioEssays 1994; 16: 565–576.

    Article  PubMed  CAS  Google Scholar 

  41. Abraham RT. Phosphatidylinositol 3-kinase related kinases. Curr Opin Immunol 1996; 8: 412–418.

    Article  PubMed  CAS  Google Scholar 

  42. Richardson A, Parsons JT. Signal transduction through integrins: a central role for focal adhesion kinase? BioEssays 1995; 17: 229–236.

    Article  PubMed  CAS  Google Scholar 

  43. Bokoch GM, Der CJ. Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J 1993; 7:750–759.

    Google Scholar 

  44. Pronk GJ, Bos JL. The role of pm“’ in receptor tyrosine kinase signalling. Biochim Biophys Acta 1994; 1198: 131–147.

    PubMed  Google Scholar 

  45. Isenberg G. Actin-binding protein-lipid interactions. Cell Motil Cytoskel 1991; 12: 136–144.

    CAS  Google Scholar 

  46. Jockusch, BM, Rüdiger, M. Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation. Trends Cell Biol 1996; 6: 311–315.

    Article  PubMed  CAS  Google Scholar 

  47. Jockusch BM, Bubeck P, Giehl K, Kroemker M, Moschner J, Rothkegel M, Rüdiger M, Schlüter K, Stanke G, Winkler J. The molecular architecture of focal adhesions. Annu Rev Cell Dev Biol 11: 379–416.

    Google Scholar 

  48. Songyang Z, Cantley LC. Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends Biochem Sci 1995; 20: 470–475.

    Article  PubMed  CAS  Google Scholar 

  49. Wittenberg C, Reed SI. Plugging it in: signaling circuits and the yeast cell cycle. Curr Opin Cell Biol 8: 223–230.

    Google Scholar 

  50. Faux MC, Scott JD. Molecular glue: kinase anchoring and scaffold proteins. Cell 1996; 85: 9–12.

    Article  PubMed  CAS  Google Scholar 

  51. Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 1995; 268: 247–251.

    Article  PubMed  CAS  Google Scholar 

  52. Li Y, Carraway, KL, Carraway CAC. Molecular Associations of teh care glycoprotein complex from a microfilamnet-associated signal transduction particle from ascite tumor cell microvilli. Submitted.

    Google Scholar 

  53. Garner CC, Kindler S. Synaptic proteins and assembly of synaptic junctions. Trends Cell Biol 1996; 6: 429–433.

    Article  PubMed  CAS  Google Scholar 

  54. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 1996; 275: 73–77.

    Article  Google Scholar 

  55. Henry MD, Campbell KP. Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton. Curr Opin Cell Biol 1995; 8: 625–631.

    Article  Google Scholar 

  56. Ben-Ze’ev A. Cytoskeletal and adhesion proteins as tumor suppressors. Curr Opin Cell Biol 1997; 9: 99–108.

    Article  PubMed  Google Scholar 

  57. Galisteo ML, Chernoff J, Su Y-C, Skolnik EY, Schlessinger J. The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pakm. J Biol Chem 1996; 271: 20997–21000.

    Article  PubMed  CAS  Google Scholar 

  58. Lisanti MP, Scherer PE, Tang Z, Sargiacomo M. Caveolae, caveolin and caveolinrich membrane domains: a signalling hypothesis. Trends Cell Biol 1994; 4231–235.

    Google Scholar 

  59. Posas F, Saito H. Osmotic activation of the HOG MAPK pathway via Steup MAPKKK: scaffold role of Pbs2p MAPKK. Science 1997; 276: 1702–1705.

    Article  PubMed  CAS  Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Carraway, K.L., Carraway, C.A.C., Carraway, K.L. (1998). Perspectives. In: Signaling and the Cytoskeleton. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12993-7_8

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  • DOI: https://doi.org/10.1007/978-3-662-12993-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12995-1

  • Online ISBN: 978-3-662-12993-7

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