The N-Terminal Region of the Relaxin A Chain
Relaxin as referred to in this chapter is B29 porcine relaxin which has an A chain starting with arginine and ending with cysteine, and a B chain starting with pyroglutamic acid and ending with arginine in position B29 (hence B29 relaxin). Due to the presence of pyroglutamic acid in position B1, the N-terminal region of the A chain lends itself to modifications or even to total exchange. The questions to be answered then were: 1) is the A chain N-terminal region important, and if so, 2) what is its role?
KeywordsCyanogen Bromide Pyroglutamic Acid Tert Butyl Ester Citraconic Anhydride Amino Tyrosine
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