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The N-Terminal Region of the Relaxin A Chain

  • Christian Schwabe
  • Erika E. Büllesbach

Abstract

Relaxin as referred to in this chapter is B29 porcine relaxin which has an A chain starting with arginine and ending with cysteine, and a B chain starting with pyroglutamic acid and ending with arginine in position B29 (hence B29 relaxin). Due to the presence of pyroglutamic acid in position B1, the N-terminal region of the A chain lends itself to modifications or even to total exchange. The questions to be answered then were: 1) is the A chain N-terminal region important, and if so, 2) what is its role?

Keywords

Cyanogen Bromide Pyroglutamic Acid Tert Butyl Ester Citraconic Anhydride Amino Tyrosine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Christian Schwabe
    • 1
  • Erika E. Büllesbach
    • 1
  1. 1.Medical University of South CarolinaCharlestonUSA

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