The N-Terminal Region of the Relaxin A Chain

  • Christian Schwabe
  • Erika E. Büllesbach


Relaxin as referred to in this chapter is B29 porcine relaxin which has an A chain starting with arginine and ending with cysteine, and a B chain starting with pyroglutamic acid and ending with arginine in position B29 (hence B29 relaxin). Due to the presence of pyroglutamic acid in position B1, the N-terminal region of the A chain lends itself to modifications or even to total exchange. The questions to be answered then were: 1) is the A chain N-terminal region important, and if so, 2) what is its role?


Cyanogen Bromide Pyroglutamic Acid Tert Butyl Ester Citraconic Anhydride Amino Tyrosine 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Christian Schwabe
    • 1
  • Erika E. Büllesbach
    • 1
  1. 1.Medical University of South CarolinaCharlestonUSA

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