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Prostatic Endocrine-Paracrine Cells: Recent Findings and Possible Relationship to Nodular Prostatic Hyperplasia and Prostatic Neoplasia

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Progress in Surgical Pathology

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Abstract

Endocrine-paracrine cells of the human prostate gland and urethra (APUD) have been studied recently in our laboratory. Cytochemical, immunocytochemical, and ultrastructural investigations have shown these endocrine-paracrine cells to be much more numerous and diverse than previously suspected. These endocrine-paracrine cells are of the open, closed, and dendritic types, and most, if not all, contain serotonin. A few of these cells contain somatostatin. At least four cell types can be defined by silver stains and immunocytochemistry and possibly as many as nine cell “types” based on secretory granule morphology. Endocrine-paracrine (EP) cells could play a central role in the pathogenesis of benign prostatic hyperplasia and carcinoma.

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Authors
  1. P. Anthony di Sant’Agnese
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  2. Karen L. de Mesy Jensen
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Editor information

Editors and Affiliations

  1. University of New Mexico, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  2. Albuquerque Veterans Administration Medical Center, Albuquerque, New Mexico, USA

    Cecilia M. Fenoglio-Preiser M.D. (Professor of Pathology, Director of Laboratory Services) (Professor of Pathology, Director of Laboratory Services)

  3. Columbia University College of Physicians and Surgeons, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  4. Department of Pathology, Memorial Hospital, Morristown, New Jersey, USA

    Marianne Wolff M.D. (Professor of Clinical Surgical Pathology) (Professor of Clinical Surgical Pathology)

  5. Division of Pathology and Cytology, The National Tumor Institute, Milan, Italy

    Franco Rilke M.D. (Director) (Director)

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© 1988 Springer-Verlag Berlin Heidelberg

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di Sant’Agnese, P.A., de Mesy Jensen, K.L. (1988). Prostatic Endocrine-Paracrine Cells: Recent Findings and Possible Relationship to Nodular Prostatic Hyperplasia and Prostatic Neoplasia. In: Fenoglio-Preiser, C.M., Wolff, M., Rilke, F. (eds) Progress in Surgical Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12820-6_8

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  • DOI: https://doi.org/10.1007/978-3-662-12820-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-12822-0

  • Online ISBN: 978-3-662-12820-6

  • eBook Packages: Springer Book Archive

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